Atropine Impurity N5 CAS 138-12-5
| CAS No. | 138-12-5 |
| Molecular Formula | C17H21NO4 |
| Molecular Weight | 303.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Atropine Impurity N5 (CAS 138-12-5), a pharmacopoeial impurity reference standard (molecular formula C17H21NO4, MW 303.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Atropine Impurity N5 (C17H21NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 303.35 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H21NO4 |
| Molecular Weight | 303.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Atropine Standards
- Atropine impurity 65 (CAS CATO-C4X-148965)
- Atropine EP Impurity E(7-Hydroxyhyoscyamine) (CAS 949092-65-3)
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- Atropine Impurity 32 (CAS 4438-22-6)
- Atropine Sulfate EP Impurity D (CAS CATO-C4X-148939)
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- Atropine Impurity 49 (CAS CATO-C4X-148949)
- Atropine Impurity 50 (CAS CATO-C4X-148950)
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Why CATO?
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