5-(difluoromethyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid CAS 1384427-73-9
| CAS No. | 1384427-73-9 |
| Molecular Formula | C8H10F2N2O2 |
| Molecular Weight | 204.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-(difluoromethyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-(difluoromethyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid (CAS 1384427-73-9), molecular formula C8H10F2N2O2 and molecular weight 204.17 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(difluoromethyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid (C8H10F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H10F2N2O2 |
| Molecular Weight | 204.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related difluoromethyl Standards
- 1-(Difluoromethyl)-4-iodo-1H-pyrazole (CAS 1041205-43-9)
- 2-[1-(difluoromethyl)-3,5-dimethyl-1h-pyrazol-4-yl]acetic acid (CAS 1221724-52-2)
- Ethyl 1-(difluoromethyl)-3-methyl-1H-pyrazole-5-carboxylate (CAS 128537-24-6)
- Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (CAS 141573-95-7)
- Ethyl 5-(difluoromethyl)-1-methyl-1H-pyrazole-3-carboxylate (CAS 1437312-22-5)
- Methyl 5-(difluoromethyl)-1-ethyl-1H-pyrazole-4-carboxylate (CAS 1443287-95-3)
- 5-(Difluoromethyl)-3,4-dimethoxypyridin-2-amine (CAS 1804451-51-1)
- 2-(Difluoromethyl)-3,5-dimethoxypyridin-4-amine (CAS 1805159-03-8)
Recommended Standards
- 1,1,1-Trifluoro-4-(methylsulfonyl)butan-2-one (CAS 1343593-04-3)
- 2-((3,3,3-Trifluoropropyl)sulfinyl)acetic acid (CAS 1408206-32-5)
- Ethyl 2,2-difluoro-2-(1-methyl-1h-pyrazol-5-yl)acetate (CAS 1343190-46-4)
- 2,2-Difluoro-2-(1-propyl-1h-imidazol-2-yl)acetic acid (CAS 1340453-76-0)
- 2-(3-Methoxy-5-isoxazolyl)acetic Acid (CAS 16877-55-7)
- Mc-D-Val-D-Cit-PAB (CAS CATO-C3D-262944)
- 2-(3-Chloropropoxy)ethanol (CAS 215371-02-1)
- 1,3-Diheptadecanoin (CAS 71431-35-1)
- 2-Chloro-3-(chloromethyl)pyridine hydrochloride (CAS 106651-82-5)
- Methyl 2-methyl-3-{[2-(pyrrolidin-1-yl)ethyl]amino}propanoate (CAS 1221342-48-8)
- (S)-N,N-Diethylpyrrolidine-2-carboxamide (CAS 41721-01-1)
- Methyl 6,8-dichlorochroman-3-carboxylate (CAS 885271-50-1)
- Tert-butyl n-(2-hydroxy-4-methylphenyl)carbamate (CAS 328267-64-7)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
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