Fluoxetine Impurity 46 HCL CAS 138614-32-1
| CAS No. | 138614-32-1 |
| Molecular Formula | C16H16F3NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Fluoxetine Impurity 46 HCL meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Fluoxetine Impurity 46 HCL (CAS 138614-32-1), a pharmacopoeial impurity reference standard (molecular formula C16H16F3NOHCl, MW 331.76 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Fluoxetine Impurity 46 HCL (C16H16F3NOHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 331.76 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H16F3NO HCl |
| Molecular Weight | 331.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Fluoxetine Standards
- Fluoxetine Impurity 37 (CAS 101-98-4)
- Fluoxetine Impurity 44 (CAS 101-98-4（free base）)
- Fluoxetine Impurity 19 (CAS 1026723-45-4)
- Fluoxetine Impurity 26 (CAS 103756-12-3)
- (S)-Fluoxetine Hydrochloride (CAS 114247-06-2)
- (R)-Fluoxetine Hydrochloride (CAS 114247-09-5)
- Fluoxetine oxalate, >98% (CAS 114414-02-7)
- Fluoxetine-d5 HCl (CAS 1173020-43-3)
Recommended Standards
- Osimertinib Impurity 55 (CAS 2364486-24-6)
- Abemaciclib Impurity 180 (CAS CATO-C4X-2937180)
- Vilanterol Impurity 37 (CAS 452339-70-7)
- 3-Methoxytetrahydro-2H-pyran-4-carbonitrile (CAS 1880888-03-8)
- (2,5-Dimethylthiophen-3-yl)methanamine hydrochloride (CAS 1332530-48-9)
- Ethyl 1-(propan-2-yl)cyclopropane-1-carboxylate (CAS 104131-91-1)
- 3-(1h-1,2,4-Triazol-1-yl)propanenitrile (CAS 76686-83-4)
- 3-(2,5-Difluorophenyl)-2,2-dimethylpropan-1-amine (CAS 1342145-69-0)
- tert-Butyl 4-(5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)piperidine-1-carboxylate (CAS 1033194-50-1)
- Macrophage Inhibitory Peptide (CAS 41961-56-2)
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