Abemaciclib Impurity 180 CAS CATO-C4X-2937180

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-2937180
Molecular FormulaC16H11FN2
Molecular Weight250.27 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Abemaciclib Impurity 180 CAS CATO-C4X-2937180 chemical structure

Description

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Abemaciclib Impurity 180 is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 250.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

Abemaciclib Impurity 180 (CAS CATO-C4X-2937180) is a certified pharmaceutical impurity reference standard with the molecular formula C16H11FN2 and a molecular weight of 250.27 g/mol.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Abemaciclib Impurity 180 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC16H11FN2
Molecular Weight250.27 g/mol
Purity≥95%
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentF-containing
Nitrogen Atoms2

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