Clomifene Citrate EP Impurity D CAS 1391054-64-0
| CAS No. | 1391054-64-0 |
| Molecular Formula | C38H46N2O3 |
| Molecular Weight | 578.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clomifene Citrate EP Impurity D is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Clomifene Citrate EP Impurity D (CAS 1391054-64-0) is a certified pharmaceutical impurity reference standard with the molecular formula C38H46N2O3 and a molecular weight of 578.78 g/mol.
Clomifene Citrate EP Impurity D (C38H46N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C38H46N2O3 |
| Molecular Weight | 578.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
Related Clomifene Standards
- Clomifene Impurity 18 (CAS CATO-C4X-151218)
- Clomifene Impurity 19 (CAS CATO-C4X-151219)
- Clomifene (CAS 911-45-5)
- Clomifene EP Impurity A (CAS 19957-52-9)
- Clomifene Impurity 9 (CAS 113454-71-0)
- Clomifene EP Impurity B (CAS 796-77-0)
- Clomifene Impurity 7 (CAS 58280-04-9)
- Clomifene Impurity 8 (CAS 23464-17-7)
Recommended Standards
- 9,9,9',9',9'',9''-Hexamethyl-9H,9'H,9''H-2,2':7',2''-terfluorene (CAS 851478-90-5)
- Timosaponin AI (CAS 68422-00-4)
- (((2R,3R,4S,5R,6R)-2-Iodo-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl)tris(oxy))tris(trimethylsilane) (CAS 352432-46-3)
- 6,6'-((Ethane-1,2-diylbis(azanylylidene))bis(methanylylidene))bis(4-(tert-butyl)-2-(morpholinomethyl)phenol) (CAS 252735-70-9)
- Bevantolol Impurity 6 (CAS 42865-04-3)
- Ibrutinib Impurity 82 (CAS 1516569-46-2)
- Crisaborole impurity 130 (CAS CATO-C4X-2021130)
- 6-(Hydroxymethyl)pyridine-3-boronic Acid (CAS 913835-98-0)
- Ceftaroline Fosamil Impurity 13 (CAS 189345-52-6)
- L-2,2-Dimethyl-thiaproline hydrochloride (CAS 213475-47-9)
- 2,5-Dioxopyrrolidin-1-yl cyclopentanecarboxylate (CAS 51871-58-0)
- 4-Chloro-3-(difluoromethyl)-5-(trifluoromethyl)picolinonitrile (CAS 1805361-18-5)
- (5-Oxopyrrolidin-3-yl)methyl 4-methylbenzenesulfonate (CAS 1005474-47-4)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
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