Crisaborole impurity 130 CAS CATO-C4X-2021130
| CAS No. | CATO-C4X-2021130 |
| Molecular Formula | C27H30BrNO4Si |
| Molecular Weight | 540.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Crisaborole impurity 130 (CAS CATO-C4X-2021130) is a certified pharmaceutical impurity reference standard with the molecular formula C27H30BrNO4Si and a molecular weight of 540.52 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Crisaborole impurity 130 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 540.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H30BrNO4Si |
| Molecular Weight | 540.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Crisaborole Standards
- Crisaborole lmpurity 88 (CAS CATO-C4X-202188)
- Crisaborole lmpurity 82 (CAS CATO-C4X-202182)
- Crisaborole Impurity 53 (CAS 2850341-51-2)
- Crisaborole Impurity 49 (CAS CATO-C4X-2021149)
- Crisaborole Impurity 29 (CAS CATO-C4X-202129)
- Crisaborole Impurity 71 (CAS CATO-C4X-202171)
- Crisaborole Impurity 139 (CAS CATO-C4X-2021139)
- Crisaborole lmpurity 86 (CAS CATO-C4X-202186)
Recommended Standards
- Aloeresin A (CAS 74545-79-2)
- Oleuropein (CAS 32619-42-4)
- Capreomycin IIA (CAS 62639-89-8)
- Oleuroside (CAS 116383-31-4)
- Tiotropium Impurity 28 (CAS 59516-66-4)
- Azacitidine Impurity 13 (CAS CATO-C4X-138813)
- Aprepitant Impurity 24 (CAS 327623-36-9)
- N-(2-(4-(4-chlorophenyl)piperazin-1-yl)-2-oxoethyl)-3-methylbenzamide (CAS 338419-57-1)
- (R,Z)-2-(4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-yl)allyl)piperazin-1-yl)ethan-1-ol (CAS CATO-CIM-100236)
- 4-[[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]amino]-4-oxo-butanoic acid (CAS 1488107-60-3)
- Venetoclax Impurity 140 (CAS CATO-C4X-2495140)
- 5-Methyl-4-phenylpyrimidine-2-thiol (CAS 857412-75-0)
- 2-Chloro-N-(4-iodophenyl)benzamide (CAS 303122-24-9)
- Tirzepatide Impurity 15 (CAS CATO-C4X-324015)
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