Folic Acid EP Impurity E CAS 1391068-26-0
| CAS No. | 1391068-26-0 |
| Molecular Formula | C26H24N12O7 |
| Molecular Weight | 616.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C26H24N12O7, Folic Acid EP Impurity E contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 616.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Folic Acid EP Impurity E (CAS 1391068-26-0) is a certified pharmaceutical impurity reference standard with the molecular formula C26H24N12O7 and a molecular weight of 616.54 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H24N12O7 |
| Molecular Weight | 616.54 g/mol |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 12 |
Related Folic Standards
- Folic Acid EP Impurity H (CAS 2366274-27-1)
- Folic Acid NHS Ester (gamma : alpha =2 :1) (CAS 153445-05-7)
- Folic Acid Impurity 71 (CAS CATO-C4X-139571)
- Folic Acid Impurity 46 Disodium Salt (CAS 914800-65-0)
- Folic Acid Impurity 63 (CAS CATO-C4X-139563)
- Folic Acid Impurity 35 (CAS 33157-07-2)
- Folic Acid-D5 N-Nitroso (CAS CATO-C4X-139568)
- Folic Acid Impurity 56 (CAS CATO-C4X-139556)
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- 5-Cyclopropoxypyridine-3,4-dicarbaldehyde (CAS 1243456-67-8)
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