4-(Thiophen-2-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine CAS 1396674-50-2
| CAS No. | 1396674-50-2 |
| Molecular Formula | C16H16F3NO3S2 |
| Molecular Weight | 391.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Thiophen-2-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine.
4-(Thiophen-2-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine (CAS 1396674-50-2), molecular formula C16H16F3NO3S2 and molecular weight 391.43 g/mol, is a CATO reference standard with documented purity and traceability.
4-(Thiophen-2-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine (C16H16F3NO3S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(Thiophen-2-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16F3NO3S2 |
| Molecular Weight | 391.43 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Thiophen Standards
- 4-(3-(Thiophen-2-yl)-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)benzyl)piperidine (CAS 1096443-08-1)
- 2,2'-((2-((4,6-Di(thiophen-2-yl)pyrimidin-2-yl)oxy)ethyl)azanediyl)diethanol (CAS 124959-48-4)
- Methyl 1-(3-(thiophen-2-yl)-3-(2,2,2-trifluoroacetamido)propanoyl)piperidine-4-carboxylate (CAS 439107-50-3)
- Ethyl 4-(2-((6-(thiophen-2-yl)pyridazin-3-yl)thio)acetyl)piperazine-1-carboxylate (CAS 872704-13-7)
- N-(Thiophen-2-ylmethyl)-1-(6-(o-tolyl)pyridazin-3-yl)piperidine-4-carboxamide (CAS 1105232-97-0)
- 3-(Thiophen-2-yl)-6-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)pyridazine (CAS 946275-02-1)
- 7-[(E)-2-[(Thiophen-2-yl)methylidene]hydrazin-1-yl]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338962-15-5)
- 4-(4-(Thiophen-2-yl)pyrimidin-2-yl)phenyl 4-chlorobenzoate (CAS 477862-92-3)
Recommended Standards
- N-(3-(4-Phenylpiperazin-1-yl)propyl)-2-(trifluoromethyl)benzamide (CAS 1049395-87-0)
- 3-(3,5-Dimethylbenzenesulfonyl)-6,7-difluoro-1-propyl-1,4-dihydroquinolin-4-one (CAS 1547050-53-2)
- Fmoc-His(1-Me)-OH (CAS 202920-22-7)
- 4-(7-(2,5-Difluorophenyl)-1,4-thiazepane-4-carbonyl)phenyl acetate (CAS 1705252-03-4)
- [3-(3-Methylpiperidin-1-yl)propyl]-(2-thienylmethyl)amine (CAS 1173265-34-3)
- 1-[4-(3-Chloropropoxy)-3-methoxyphenyl]ethanone-d3 (CAS 1071167-68-4)
- L-Phenylalanine-d7 (CAS 69113-60-6)
- 2-Phenyl-2-(1H-pyrrol-1-yl)-N-(2,2,2-trifluoroethyl)acetamide (CAS 1351582-39-2)
- Eethyl 5-ethynylthiophene-3-carboxylate (CAS 216444-07-4)
- 2-(1-(Piperidin-4-yl)-1H-1,2,3-triazol-4-yl)ethan-1-ol hydrochloride (CAS 1774898-52-0)
- (S)-1-Cbz-2-isopropyl-piperazine (CAS 1023964-84-2)
- Tert-butyl 5-amino-2-methylnicotinate (CAS 1250956-12-7)
- 5,5-Dimethylthiazolidine-4-carboxylic acid (CAS 15260-83-0)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com