4-(3-(Thiophen-2-yl)-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)benzyl)piperidine CAS 1096443-08-1
| CAS No. | 1096443-08-1 |
| Molecular Formula | C20H20F3N3S |
| Molecular Weight | 391.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(3-(Thiophen-2-yl)-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)benzyl)piperidine.
4-(3-(Thiophen-2-yl)-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)benzyl)piperidine (CAS 1096443-08-1), molecular formula C20H20F3N3S and molecular weight 391.45 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(3-(Thiophen-2-yl)-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)benzyl)piperidine (C20H20F3N3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(3-(Thiophen-2-yl)-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)benzyl)piperidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20F3N3S |
| Molecular Weight | 391.45 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Thiophen Standards
- 4-(Thiophen-2-yl)-1-((4-(trifluoromethoxy)phenyl)sulfonyl)piperidine (CAS 1396674-50-2)
- 2,2'-((2-((4,6-Di(thiophen-2-yl)pyrimidin-2-yl)oxy)ethyl)azanediyl)diethanol (CAS 124959-48-4)
- Methyl 1-(3-(thiophen-2-yl)-3-(2,2,2-trifluoroacetamido)propanoyl)piperidine-4-carboxylate (CAS 439107-50-3)
- Ethyl 4-(2-((6-(thiophen-2-yl)pyridazin-3-yl)thio)acetyl)piperazine-1-carboxylate (CAS 872704-13-7)
- N-(Thiophen-2-ylmethyl)-1-(6-(o-tolyl)pyridazin-3-yl)piperidine-4-carboxamide (CAS 1105232-97-0)
- 3-(Thiophen-2-yl)-6-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)pyridazine (CAS 946275-02-1)
- 7-[(E)-2-[(Thiophen-2-yl)methylidene]hydrazin-1-yl]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338962-15-5)
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Recommended Standards
- Prazosin-D8 (CAS 1006717-55-0)
- 1-(2-((3-(Pyridin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)phenyl)-3-(thiophen-2-ylmethyl)urea (CAS 1797959-93-3)
- Torasemide Impurity 45 (CAS CATO-C4X-183645)
- 2-((4-Oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)-N-(o-tolyl)acetamide (CAS 847773-16-4)
- (S)-Bupropion (CAS CATO-C4X-120334)
- Methyl 13-nitro-2,3,5,6,8,9-hexahydrobenzo[b][1,4,7,10]tetraoxacyclododecine-12-carboxylate (CAS 1403772-23-5)
- 6-Bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (CAS 1379360-58-3)
- 1-Formylcyclobutanecarbonitrile (CAS 1918186-21-6)
- trans-3-fluorocyclobutanol (CAS 1262278-60-3)
- Ibrutinib Impurity 158 (CAS CATO-C4X-1064158)
- Pravastatin EP Impurity E Sodium Salt (CAS 722504-45-2)
- N-[(1S)-2-Hydroxy-3-methyl-1-(2-methylpropyl)-3-buten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester (CAS 1609959-45-6)
- Ethyl 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carboxylate (CAS 185040-33-9)
- Glu17-Semaglutide (CAS CATO-C4X-2226209)
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