Simvastatin EP Impurity A Ammonium Salt CAS 139893-43-9
| CAS No. | 139893-43-9 |
| Molecular Formula | C25H40O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Simvastatin EP Impurity A Ammonium Salt (CAS 139893-43-9) is a certified pharmaceutical impurity reference standard with the molecular formula C25H40O6H3N and a molecular weight of 453.62 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Simvastatin EP Impurity A Ammonium Salt is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 453.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C25H40O6 H3N |
| Molecular Weight | 453.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 1 |
Related Simvastatin Standards
- Simvastatin D3 (CAS 1002347-61-6)
- Simvastatin-d6 (CAS 1002347-71-8)
- Simvastatin-d11 (CAS 1002347-74-1)
- Simvastatin EP Impurity A(Sodium Salt) (CAS 101314-97-0)
- Simvastatin EP Impurity A-d6 Sodium Salt (CAS 101314-97-0 (unlabelled))
- Simvastatin impurity 01 (CAS 1092716-42-1)
- Simvastatin Impurity I (CAS 121624-18-8)
- Simvastatin Impurity 8 (CAS 130468-11-0)
Recommended Standards
- Iguratimod Impurity 50 (CAS CATO-C4X-182650)
- Ilaprazole impurity 183 (CAS CATO-C4X-1130183)
- Bicalutamide EP Impurity E (CAS CATO-C4X-101325)
- Anastrozole Impurity 19 (CAS 918312-71-7)
- 1-(3-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid Methyl Ester (CAS 1568-36-1)
- 2-(Chloromethyl)-5-(3-methyl-4-nitrophenyl)-1,3,4-oxadiazole (CAS 298187-48-1)
- 1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-1-one (CAS 2126952-65-4)
- (S)-2-Amino-N-cyclopropyl-3-methyl-N-(4-methylbenzyl)butanamide (CAS 1307224-35-6)
- 3,4-Dibromo-1-(cyclopropylmethyl)-1H-pyrrol-2(5H)-one (CAS 1706437-77-5)
- T-Peptide (CAS 2022956-62-1)
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