Crizotinib 2-Keto Impurity CAS 1415558-82-5
| CAS No. | 1415558-82-5 |
| Molecular Formula | C21H20Cl2FN5O2 |
| Molecular Weight | 464.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C21H20Cl2FN5O2, Crizotinib 2-Keto Impurity contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 464.32 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Crizotinib 2-Keto Impurity (CAS 1415558-82-5, C21H20Cl2FN5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Crizotinib 2-Keto Impurity meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20Cl2FN5O2 |
| Molecular Weight | 464.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 12 (CAS CATO-C4X-102512)
- Crizotinib impurity 13 (CAS CATO-C4X-102513)
- Crizotinib impurity 21 (CAS CATO-C4X-102521)
- Crizotinib impurity 25 (CAS CATO-C4X-102525)
- Crizotinib-d5 (CAS 1395950-48-7)
- Crizotinib impurity 34 (CAS CATO-C4X-102534)
- Crizotinib impurity 35 (CAS CATO-C4X-102535)
- Crizotinib impurity 40 (CAS CATO-C4X-102540)
Recommended Standards
- 1-[(4-Bromophenyl)methyl]-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine (CAS 1031206-96-8)
- 2-(4-Bromo-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl)-1-phenylethanethione (CAS 140405-98-7)
- tert-Butyl 4-(2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-3,3-difluoropiperidine-1-carboxylate (CAS 2058321-97-2)
- 1-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((4-chlorophenyl)thio)propan-1-one (CAS 634155-05-8)
- Roxithromycin Impurity 18 (CAS 67796-27-4)
- Pyridoxine Impurity 74 (CAS CATO-C4X-187774)
- Riluzole Impurity 4 (CAS 144631-82-3)
- 2-hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl dihydrogen phosphate (CAS 1111616-69-3)
- Emetine hydrochloride (CAS 14198-59-5)
- tert-Butyl (5,6,7,8-tetrahydroquinazolin-6-yl)carbamate (CAS 1440526-58-8)
- (4-Chlorophenyl)hydrazine hemisulfate (CAS 14581-21-6)
- 1-(3,4-Dichlorobenzyl)-3-((2,4,6-trichlorophenyl)diazenyl)-1H-indol-2-ol (CAS 303985-19-5)
- 3-(2-Methylpyridin-3-yl)prop-2-enoic acid (CAS 118419-95-7)
- [α-Glu](Sidechain trans-position)-Liraglutide (CAS CATO-C4X-199240)
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