Crizotinib impurity 25 CAS CATO-C4X-102525
| CAS No. | CATO-C4X-102525 |
| Molecular Formula | C21H22Cl2FN5O2 |
| Molecular Weight | 466.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Crizotinib impurity 25 (CAS CATO-C4X-102525) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22Cl2FN5O2 and a molecular weight of 466.34 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Crizotinib impurity 25 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 466.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Crizotinib impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H22Cl2FN5O2 |
| Molecular Weight | 466.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 90+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Crizotinib Standards
- Crizotinib impurity 12 (CAS CATO-C4X-102512)
- Crizotinib impurity 13 (CAS CATO-C4X-102513)
- Crizotinib impurity 21 (CAS CATO-C4X-102521)
- Crizotinib 2-Keto Impurity (CAS 1415558-82-5)
- Crizotinib-d5 (CAS 1395950-48-7)
- Crizotinib impurity 34 (CAS CATO-C4X-102534)
- Crizotinib impurity 35 (CAS CATO-C4X-102535)
- Crizotinib impurity 40 (CAS CATO-C4X-102540)
Recommended Standards
- Mosapride Impurity 22 (CAS CATO-C4X-104422)
- 4,4'-(Propane-1,3-diylbis(oxy))bis(5-methoxy-2-nitrobenzoic acid) (CAS 140658-45-3)
- 2-((5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N,N-diphenylacetamide (CAS 332161-53-2)
- N-[4-({1-[(3,4-dichlorophenyl)methyl]-6-oxo-1,6-dihydropyridin-3-yl}sulfamoyl)phenyl]acetamide (CAS 339009-16-4)
- Velpatasvir impurity 16 (CAS CATO-C4X-289416)
- Dabigatran Impurity 107 (CAS CATO-C4X-1089107)
- Mosapride Impurity 8 (CAS 112885-33-3)
- (R,R)-Hydroxy Bupropion (CAS 192374-15-5)
- (E)-Ethyl 3-(4-(1-(2-(isoindolin-5-yl)-ethyl)pyrrolidin-2-yl)phenyl)acrylate 1706519-94-9 (CAS 1706519-94-9)
- (E)-2-(4-Chlorostyryl)quinoline (CAS 38101-91-6)
- 1H-Pyrrolizin-2(3H)-one (CAS 89059-09-6)
- 3-Methyl-4-(pentyloxy)benzenesulfonamide (CAS 1094491-12-9)
- 2-Hydrazinyl-4-(3-methoxyphenyl)-6-(trifluoromethyl)pyrimidine (CAS 861440-89-3)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
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