Rivaroxaban EP Impurity E CAS 1415566-28-7
| CAS No. | 1415566-28-7 |
| Molecular Formula | C19H19N3O5S |
| Molecular Weight | 401.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rivaroxaban EP Impurity E.
CATO supplies Rivaroxaban EP Impurity E (CAS 1415566-28-7), a pharmacopoeial impurity reference standard (molecular formula C19H19N3O5S, MW 401.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Rivaroxaban EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 401.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Rivaroxaban EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H19N3O5S |
| Molecular Weight | 401.44 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 215 (CAS CATO-C4X-1090215)
- Rivaroxaban Impurity 65 (CAS 73311-47-4)
- Rivaroxaban Impurity 123 (CAS CATO-C4X-1090123)
- Rivaroxaban Desmorpholinone Analog (CAS 936232-22-3)
- Rivaroxaban impurity 176 (CAS CATO-C4X-1090176)
- Rivaroxaban impurity 196 (CAS CATO-C4X-1090196)
- Rivaroxaban Impurity 39 (CAS 446292-07-5)
- Rivaroxaban Impurity 43 (CAS 1369969-44-7)
Recommended Standards
- Open-ring Desulfated Aztreonam Ethyl Ester 1 (CAS CATO-C4X-152212)
- N-phenyl-3-(phenylsulfonyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 904575-84-4)
- Open-ring Desulfated Aztreonam Ethyl Ester 3 (CAS CATO-C4X-1522122)
- N-[4-({[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methyl}sulfamoyl)phenyl]acetamide (CAS 339016-84-1)
- Crisaborole lmpurity 70 (CAS CATO-C4X-202170)
- Ribavirin EP Impurity A (CAS 39925-19-4)
- Lurbinectedin Impurity 33 (CAS CATO-C4X-311433)
- 2,4-Dichloro-n-(pyridin-3-ylmethyl)aniline (CAS 84324-64-1)
- H-Gln-AMC (CAS 105888-45-7)
- 1-(2-Chloro-10H-phenothiazin-10-yl)-3-(4-methylpiperazin-1-yl)propan-1-one (CAS 19077-28-2)
- 7-Methoxy-4,5-dihydro-1H-benzo[c]azepin-3(2H)-one (CAS 66191-66-0)
- 1,3-dimethyl-5-(pyridin-3-yloxy)-1H-pyrazole-4-carboxylic acid (CAS 1152561-56-2)
- 2-Chloro-4-morpholinobenzaldehyde (CAS 886501-36-6)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
Why CATO?
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