2-[4-(Trifluoromethyl)phenyl]glycine CAS 142012-65-5
| CAS No. | 142012-65-5 |
| Molecular Formula | C9H8F3NO2 |
| Molecular Weight | 219.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-[4-(Trifluoromethyl)phenyl]glycine (CAS 142012-65-5) is a high-purity analytical reference standard with the molecular formula C9H8F3NO2 and a molecular weight of 219.16 g/mol.
2-[4-(Trifluoromethyl)phenyl]glycine (C9H8F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8F3NO2 |
| Molecular Weight | 219.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
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Recommended Standards
- 2-Methyl-1-nitro-4-(2,2,2-trifluoroethyl)benzene (CAS 1404193-89-0)
- 1-(3-(2,2,2-Trifluoroethoxy)pyridin-4-yl)ethanone (CAS 1427522-50-6)
- 2-Amino-5-(2,2,2-trifluoroethyl)benzoic acid (CAS 1393558-86-5)
- (<I>S</I>)-(+)-citronellyl bromide (CAS 143615-81-0)
- Celecoxib USP Related Compound C (CAS 170570-09-9)
- 4-(2-Phenyl-6-((phenylthio)methyl)pyrimidin-4-yl)morpholine (CAS 303147-15-1)
- Ethyl 4-Methyl-2-cyclohexanone-1-carboxylate (CAS 13537-82-1)
- (5bR,11bR)-1,2,5b,11b-Tetrahydro-2-(1-methylethenyl)-6H-furo[2′,3′:6,7]benzofuro[3,2-c][1]benzopyran-9-ol (CAS 213912-46-0)
- trans-1-tert-Butyl 3-ethyl 4-methylpyrrolidine-1,3-dicarboxylate (CAS 1895053-81-2)
- 2,3-Dihydro-1H-inden-1-yl acetate (CAS 26452-98-2)
- Glycine, N-(carboxymethyl)-N-[(3-ethenylphenyl)methyl]-, sodium salt, polymer with N-(carboxymethyl)-N-[(4-ethenylphenyl)methyl]glycine sodium salt, 1-(chloromethyl)-3-ethenylbenzene, 1-(chloromethyl)-4-ethenylbenzene, 1-(dichloromethyl)-3-ethenylbenzene, (CAS 68517-08-8)
- (S)-tert-Butyl 3-((4-methylpyrimidin-2-yl)amino)pyrrolidine-1-carboxylate (CAS 1261234-41-6)
- Benzyl 1-hydroxy-6-azaspiro[3.4]octane-6-carboxylate (CAS 1419101-06-6)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
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