1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione CAS 1420776-15-3
| CAS No. | 1420776-15-3 |
| Molecular Formula | C12H9ClF3N3O2 |
| Molecular Weight | 319.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione.
CATO supplies 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 1420776-15-3), a certified reference material (molecular formula C12H9ClF3N3O2, MW 319.67 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 319.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H9ClF3N3O2 |
| Molecular Weight | 319.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- Ethyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1h-pyrazole-3-carboxylate (CAS 1006336-63-5)
- 1-[4-Chloro-3-(trifluoromethyl)phenyl]-5-ethyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1096912-00-3)
- (4Z)-4-{[(5-chloro-2-hydroxyphenyl)amino]methylidene}-1-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 320425-04-5)
- 1-(2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-1H-pyrrole-2,5-dione (CAS 339096-64-9)
- Methyl (1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrol-2-yl)carbamate (CAS 338407-31-1)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1-methyl-1H-imidazole-2-carbohydrazide (CAS 400078-06-0)
- N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}-2-(1H-1,2,4-triazol-1-yl)ethanimidamide (CAS 477852-40-7)
- Ethyl 4-chloro-8-(trifluoromethoxy)quinoline-3-carboxylate (CAS 1040013-63-5)
Recommended Standards
- Ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 1128268-00-7)
- Ethyl 2-(2-chlorophenyl)-5-(trifluoromethyl)-2H-1,2,3-triazole-4-carboxylate (CAS 1431729-86-0)
- 4-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-N-(2,2,2-trifluoroethyl)benzamide (CAS 1119449-64-7)
- 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl (3-chlorophenyl)carbamate (CAS 477713-69-2)
- 2-(Aminomethyl)-3-fluoro-n,n-dimethylbenzene-1-sulfonamide hydrochloride (CAS 1384431-30-4)
- Glycolaldehyde-2- (CAS 478529-67-8)
- 5-Fluoro-2-nitrotoluene (CAS 446-33-3)
- (r)-n-(Piperidin-3-yl)quinazolin-4-amine dihydrochloride (CAS 1439894-63-9)
- 3-Amino-N-isobutylbenzamide (CAS 81882-64-6)
- Ethyl 2-amino-6-(trifluoromethoxy)benzoate (CAS 1261455-28-0)
- 4-Fluorobenzo[d]thiazole-2-carboxylic acid (CAS 479028-70-1)
- 4-bromo-6,7-dihydro-5H-isoquinolin-8-one (CAS 1428651-86-8)
- 4-Ethyl-3-{[(4-methylphenyl)methyl]sulfanyl}-5-[1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]-4H-1,2,4-triazole (CAS 778579-04-7)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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