Apixaban Impurity 10 CAS 1421823-20-2
| CAS No. | 1421823-20-2 |
| Molecular Formula | C27H29ClN4O5 |
| Molecular Weight | 525.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Apixaban Impurity 10 (C27H29ClN4O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 525.00 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Apixaban Impurity 10 (CAS 1421823-20-2, C27H29ClN4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Apixaban Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H29ClN4O5 |
| Molecular Weight | 525.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Apixaban Standards
- Apixaban Impurity 56 (CAS 1620386-62-0)
- Apixaban Impurity 188 (CAS CATO-C4X-1088188)
- Apixaban Impurity 69 (CAS CATO-C4X-108869)
- Apixaban Impurity 186 (CAS 1904628-11-0)
- Apixaban Impurity 187 (CAS 1904628-12-1)
- Apixaban Impurity 144 (CAS CATO-C4X-1088144)
- Apixaban Impurity 179 (CAS CATO-C4X-1088179)
- Apixaban Impurity 60 (CAS CATO-C4X-108860)
Recommended Standards
- BYS10- BP41 (CAS CATO-C3D-263283)
- (4-(4-Chlorophenyl)-5-(2'-fluoro-4'-propyl-[1,1'-biphenyl]-4-yl)-1H-pyrazol-1-yl)(3-methoxyphenyl)methanone (CAS 477762-84-8)
- 2-Bromo-1H,1H-perfluorodec-1-ene (CAS 51249-65-1)
- Pazopanib Impurity 39 (CAS 1252927-44-8)
- Telmisartan Impurity 98 (CAS CATO-C4X-135998)
- Dacomitinib Impurity 51 (CAS CATO-C4X-208651)
- Nifuroxazide EP Impurity E (CAS CATO-C4X-21533)
- [4-bromo-5-(difluoromethoxy)-6-fluoro-2-naphthyl] 2,2-dimethylpropanoate (CAS 2763159-26-6)
- Niraparib Impurity 34 (CAS CATO-C4X-232934)
- 2-Cyclohexyl-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione (CAS 1104637-39-9)
- sodium 6-bromo-4-(trifluoromethyl)pyridine-2-carboxylate (CAS 1909305-16-3)
- 5-Phenyl-3-[(1H-1,2,4-triazol-3-yl)amino]cyclohex-2-en-1-one (CAS 894217-85-7)
- 3-(2,6-Dichloro-4-nitrophenoxy)quinoline (CAS 315228-23-0)
- Insulin Degludec Impurity 1 (CAS 843666-26-2)
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