Rupatadine Impurity 20 CAS 1422960-88-0
| CAS No. | 1422960-88-0 |
| Molecular Formula | C33H34ClN4 |
| Molecular Weight | 522.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Rupatadine Impurity 20 (CAS 1422960-88-0, C33H34ClN4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rupatadine Impurity 20 (C33H34ClN4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.5, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 522.10 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C33H34ClN4 |
| Molecular Weight | 522.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Rupatadine Standards
- Rupatadine EP Impurity A (CAS 1354055-68-7)
- Rupatadine Impurity 35 (CAS 1632412-57-7)
- Rupatadine Impurity 45 (CAS CATO-C4X-102745)
- Rupatadine Impurity 46 (CAS CATO-C4X-102746)
- Rupatadine Impurity 44 (CAS 732962-71-9)
- Rupatadine impurity 32 (CAS CATO-C4X-102732)
- Rupatadine Impurity 43 (CAS CATO-C4X-102743)
- Rupatadine Impurity 16 (CAS CATO-C4X-102716)
Recommended Standards
- 6,8-Diiodo-3-(2-oxo-2-(thiophen-2-yl)ethyl)quinazolin-4(3H)-one (CAS 669762-29-2)
- Sodium Perfluoro-3-methylheptane SulfonateDISCONTINUED (CAS 1202827-34-6)
- 2,7-Dibromo-10-(4-bromophenyl)-9,9-dimethyl-9,10-dihydroacridine (CAS 880771-61-9)
- Sodium Perfluoro-6-methylheptanesulfonateDISCONTINUED (CAS 1202827-38-0)
- Olmesartan Medoxomil EP Impurity C (CAS 879562-26-2)
- Linezolid Impurity 36 (CAS 3459-92-5)
- Lenvatinib Impurity 96 (CAS CATO-C4X-114096)
- 5-(3-(Trifluoromethyl)benzylidene)thiazolidine-2,4-dione (CAS 327033-36-3)
- 2-((5-(3-Bromophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(o-tolyl)acetamide (CAS 336174-52-8)
- (S)-N2-Methyl-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (Pramipexole Impurity) (CAS 2301875-27-2)
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