3-(Difluoromethyl)-3-hydroxycyclobutane-1-carboxylic acid CAS 1423034-50-7
| CAS No. | 1423034-50-7 |
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(Difluoromethyl)-3-hydroxycyclobutane-1-carboxylic acid (CAS 1423034-50-7) is a high-purity analytical reference standard with the molecular formula C6H8F2O3 and a molecular weight of 166.12 g/mol.
The molecular framework of 3-(Difluoromethyl)-3-hydroxycyclobutane-1-carboxylic acid (C6H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-(Difluoromethyl)-3-hydroxycyclobutane-1-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
- 2-(difluoromethyl)furan-3-carboxylic acid (CAS 1655558-07-8)
- 5-(difluoromethyl)furan-3-carboxylic acid (CAS 1706447-96-2)
- (r)-4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 956398-62-2)
- (s)-4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 956398-60-0)
- 1-(Difluoromethyl)-3-hydroxycyclobutanecarboxylic acid (CAS 2228177-93-1)
- 2-(Difluoromethyl)tetrahydrofuran-2-carboxylic acid (CAS 2230803-69-5)
- 3-(difluoromethyl)tetrahydrofuran-3-carboxylic acid (CAS 2751620-45-6)
- 4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 83191-82-6)
Recommended Standards
- 2,2-difluoro-2-(furan-2-yl)acetic acid (CAS 1344257-62-0)
- 5,5-difluorotetrahydropyran-2-carboxylic acid (CAS 1426135-66-1)
- Biphenyl-<SUP>13</SUP>C<SUB>12</SUB> (CAS 104130-36-1)
- 3,3-Difluorotetrahydro-2H-pyran-4-carboxylic acid (CAS 1504681-05-3)
- (2-Methoxy-4-(piperidin-1-yl)phenyl)boronic acid (CAS 2225179-31-5)
- 4,6-Dimethoxypyrimidin-5-methylamine (CAS 1118786-90-5)
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- Bis(2,4,4-trimethylpentyl)phosphinic Acid (CAS 83411-71-6)
- 1-(2,3-Dihydro-1H-inden-4-yl)ethanamine (CAS 1337642-45-1)
- Glycopyrrolate Impurity 12 (CAS 131237-81-5)
- (1R,3S)-3-(trifluoromethyl)cyclohexan-1-amine hydrochloride (CAS 30933-74-5)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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