3-(difluoromethyl)tetrahydrofuran-3-carboxylic acid CAS 2751620-45-6
| CAS No. | 2751620-45-6 |
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(difluoromethyl)tetrahydrofuran-3-carboxylic acid (CAS 2751620-45-6) is a high-purity analytical reference standard with the molecular formula C6H8F2O3 and a molecular weight of 166.12 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 3-(difluoromethyl)tetrahydrofuran-3-carboxylic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 166.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-(difluoromethyl)tetrahydrofuran-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O3 |
| Molecular Weight | 166.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
Related difluoromethyl Standards
- 3-(Difluoromethyl)-3-hydroxycyclobutane-1-carboxylic acid (CAS 1423034-50-7)
- 2-(difluoromethyl)furan-3-carboxylic acid (CAS 1655558-07-8)
- 5-(difluoromethyl)furan-3-carboxylic acid (CAS 1706447-96-2)
- (r)-4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 956398-62-2)
- (s)-4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 956398-60-0)
- 1-(Difluoromethyl)-3-hydroxycyclobutanecarboxylic acid (CAS 2228177-93-1)
- 2-(Difluoromethyl)tetrahydrofuran-2-carboxylic acid (CAS 2230803-69-5)
- 4-(Difluoromethyl)-4-hydroxytetrahydro-2h-pyran-2-one (CAS 83191-82-6)
Recommended Standards
- 3-(Difluoromethoxy)tetrahydro-4H-pyran-4-one (CAS 2141137-50-8)
- 3-Cyclopropyl-2,2-difluoro-3-hydroxypropanoic acid (CAS 681240-15-3)
- 2,2-Difluoro-2-(1-hydroxycyclobutyl)acetic acid (CAS 681240-09-5)
- 3-Fluoropropanoic anhydride (CAS 2266-47-9)
- 83688-44-2 3-Hydroxy-8,9,10,11-tetrahydrobenzo[b]cyclohepta[d]pyran-6(7H)-one DTXSID00419951 (CAS 83688-44-2)
- 1-(3,4-Difluoro-5-methoxyphenyl)butan-1-one (CAS 1443322-58-4)
- Urotensin II (human) trifluoroacetate salt (CAS 251293-28-4)
- Ethyl 2-bromo-6-(trifluoromethyl)isonicotinate (CAS 1196152-48-3)
- (2e)-3-(1-Ethyl-1h-pyrazol-5-yl)prop-2-enoic acid (CAS 1613049-67-4)
- 4-(Chloromethyl)-2-(3,4-dimethylphenyl)-5-methyloxazole (CAS 932728-59-1)
- 3-Bromo-5-isopropoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-1,2,4-triazole (CAS 1630905-12-2)
- 2-bromo-2-methyl-1-phenylpropan-1-one (CAS 10409-54-8)
- Methyl 2-(4-aminopiperidin-1-yl)acetate (CAS 90152-50-4)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
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