4,4,5,5-Tetramethyl-2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1,3,2-dioxaborolane CAS 1426337-32-7
| CAS No. | 1426337-32-7 |
| Molecular Formula | C19H20BF3O4 |
| Molecular Weight | 380.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4,4,5,5-Tetramethyl-2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1,3,2-dioxaborolane (CAS 1426337-32-7), molecular formula C19H20BF3O4 and molecular weight 380.17 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,4,5,5-Tetramethyl-2-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1,3,2-dioxaborolane (C19H20BF3O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20BF3O4 |
| Molecular Weight | 380.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Tetramethyl Standards
- 2,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene (CAS 853377-10-3)
- 4,4,5,5-Tetramethyl-2-[6-(tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl]-1,3,2-dioxaborolane (CAS 849543-98-2)
- 4,4,5,5-Tetramethyl-2-(3-(phenanthren-9-yl)phenyl)-1,3,2-dioxaborolane (CAS 1417522-96-3)
- 4,4,5,5-Tetramethyl-2-(8-phenylphenanthren-2-yl)-1,3,2-dioxaborolane (CAS CATO-CIM-105129)
- (R)-6,6,10,10-tetramethyl-4,8-dioxo-2-phenethyl-9-oxa-3,5,7-triazaundecanoic acid (CAS 159634-71-6)
- 1-Benzyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine (CAS 1015242-03-1)
- N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-2-yl)pivalamide (CAS 2390149-47-8)
- N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-3-yl)pivalamide (CAS 2390149-46-7)
Recommended Standards
- 5,5'-Dibromo-3,3',4,4'-tetramethyl-2,2'-bithiophene (CAS 174586-97-1)
- 1H,1H,1H,2H-Perfluorooctanethiol (CAS 34451-26-8)
- Tert-butyl 5-bromo-6-(trifluoromethoxy)indole-1-carboxylate (CAS 2227479-96-9)
- Ethyl 2-bromo-4-(4-(trifluoromethyl)-phenyl)thiazole-5-carboxylate (CAS 1188153-49-2)
- 2-((3,4,4-Trifluorobut-3-en-1-yl)thio)-1H-benzo[d]imidazole (CAS 338750-29-1)
- 5-Iodo-3-methylisothiazole-4-carboxylic acid (CAS 1383546-18-6)
- 2,3-Difluoro-6-Nitrophenol (CAS 82419-26-9)
- tert-Butyl 4-bromo-1-methyl-1H-1,2,3-triazole-5-carboxylate (CAS 1874642-98-4)
- Crisaborole impurity 157 (CAS CATO-C4X-2021157)
- Bis(1,3-bis(trimethylsilyl)cycl-ope-antadienyl)-zirconiumdichloride (CAS 60938-62-7)
- N-(Morpholinomethyl)ethanamine (CAS 507277-68-1)
- 4-((3-Allyl-2-hydroxybenzylidene)amino)-3-(pyridin-2-yl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497823-90-2)
- Bosutinib Impurity 10 (CAS 219786-51-3)
- Semaglutide Impurity 14(Discontinued,See CPTD788307 ) (CAS CATO-C4X-222614)
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