Cinacalcet Impurity 6 CAS 1428118-39-1
| CAS No. | 1428118-39-1 |
| Molecular Formula | C22H22F3N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C22H22F3NHCl, Cinacalcet Impurity 6 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 393.88 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Cinacalcet Impurity 6 (CAS 1428118-39-1, C22H22F3NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cinacalcet Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22F3N HCl |
| Molecular Weight | 393.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Cinacalcet Standards
- Cinacalcet Impurity 37 (CAS 100485-59-4)
- Cinacalcet Impurity N52 (CAS 1005450-55-4)
- Cinacalcet Impurity 29 (CAS 1020414-30-5)
- Cinacalcet Dihydro Impurity 1 Hydrochloride Salt (CAS 1020414-33-8)
- Cinacalcet Impurity 34 (CAS 1025064-33-8)
- Cinacalcet Impurity N97 (CAS 103324-39-6)
- Cinacalcet Impurity 50 (CAS 1034094-54-6)
- Cinacalcet Impurity 48 (CAS 10420-89-0)
Recommended Standards
- N-Acetyltryptophan EP Impurity G HCl (CAS 881025-90-7)
- Clodronate Disodium EP Impurity A Pyridinium Salt (CAS 134757-52-1)
- Azithromycin Impurity 26 (CAS CATO-C4X-100326)
- N-(5-Amino-2-methoxyphenyl)-2-methylbenzamide (CAS 926247-85-0)
- 1,3-Bis(2-chlorophenyl)propane-1,3-dione (CAS 942359-32-2)
- 5-(4-Fluorophenoxymethyl)-1,3,4-oxadiazole-2-thiol (CAS 445224-41-9)
- N-nitroso Rifamycin Impurity 17 (CAS CATO-C4X-200417)
- N-[3-(1H-imidazol-1-yl)propyl]-4-methyl-1,3-benzothiazol-2-amine (CAS 1177334-28-9)
- Valaciclovir EP Impurity J(hydrochloride) (CAS CATO-C4X-124827)
- Semaglutide impurity 26 (CAS CATO-C4X-222626)
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