Clodronate Disodium EP Impurity A Pyridinium Salt CAS 134757-52-1
| CAS No. | 134757-52-1 |
| Molecular Formula | C4H10Cl2O6P2 |
| Molecular Weight | 286.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clodronate Disodium EP Impurity A Pyridinium Salt (CAS 134757-52-1, C4H10Cl2O6P2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Clodronate Disodium EP Impurity A Pyridinium Salt (C4H10Cl2O6P2) contains a carbohydrate-derived structure, a phosphate ester group, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Clodronate Disodium EP Impurity A Pyridinium Salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H10Cl2O6P2 |
| Molecular Weight | 286.97 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | -1.0 |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
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