N-(1-Hydroxy-2-methylpropan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide CAS 1428352-44-6
| CAS No. | 1428352-44-6 |
| Molecular Formula | C11H17N3O3 |
| Molecular Weight | 239.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(1-Hydroxy-2-methylpropan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide (CAS 1428352-44-6), molecular formula C11H17N3O3 and molecular weight 239.27 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(1-Hydroxy-2-methylpropan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide (C11H17N3O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(1-Hydroxy-2-methylpropan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H17N3O3 |
| Molecular Weight | 239.27 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 3 |
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Recommended Standards
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- DL-3-(3,4-Dihydroxyphenyl)-2-methylalanine Ethyl Ester (CAS 14298-24-9)
- 3’-Bromo-4’-hydroxyacetophenone (CAS 1836-06-2)
- Pivampicillin Hydrochloride (CAS 26309-95-5)
- (2E)-3-{4-[(1E)-3-(4-bromophenyl)-3-oxoprop-1-en-1-yl]phenyl}-1-(4-fluorophenyl)prop-2-en-1-one (CAS 400081-35-8)
- 1-(2-Nitrobenzyl)-1H-pyrrole-2-carbonitrile (CAS 27046-47-5)
- 1,2-Bis(4-(pyridin-4-yl)phenyl)ethyne (CAS 1189377-77-2)
- N-cyano-n,o-dimethylisourea (CAS 94134-02-8)
- 2-(4-Aminophenyl)-1-ethyl-5-methyl-1H-pyrazol-3(2H)-one (CAS 194799-52-5)
- Abemaciclib Impurity 167 (CAS CATO-C4X-2937167)
- (3E)-4-[(4-Chlorophenyl)amino]-1,1,1-trifluoropent-3-en-2-one (CAS 338393-32-1)
- D-[Thr]5-Semaglutide (CAS CATO-C4X-2226245)
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