3-(chloromethyl)-1-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one CAS 1432679-72-5
| CAS No. | 1432679-72-5 |
| Molecular Formula | C4H6ClN3O |
| Molecular Weight | 147.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(chloromethyl)-1-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1432679-72-5), molecular formula C4H6ClN3O and molecular weight 147.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(chloromethyl)-1-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one (C4H6ClN3O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(chloromethyl)-1-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H6ClN3O |
| Molecular Weight | 147.56 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related chloromethyl Standards
- (4-(Chloromethyl)oxazol-2-yl)methanol (CAS 1240605-93-9)
- 3-(Chloromethyl)-4-methyl-1H-1,2,4-triazol-5(4H)-one (CAS 1338226-21-3)
- 2-(Chloromethyl)-5-methylisoxazol-3(2H)-one (CAS 69513-43-5)
- 5-(chloromethyl)-3-methoxy-1,2-oxazole (CAS 35166-40-6)
- 5-(Chloromethyl)-3-ethyl-4,5-dihydro-1,2-oxazole (CAS 1311317-47-1)
- 6-(chloromethyl)piperidin-2-one (CAS 1315366-70-1)
- 1-(3-(Chloromethyl)azetidin-1-yl)ethan-1-one (CAS 1872005-46-3)
- 1-(Chloromethyl)piperidin-2-one (CAS 68116-79-0)
Recommended Standards
- 5-Chloro-4-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 135692-47-6)
- 3-Chloro-1-(methoxymethyl)-1H-1,2,4-triazole (CAS 1573547-46-2)
- 5-Chloro-1-(methoxymethyl)-1H-1,2,4-triazole (CAS 1785762-61-9)
- 3-Chloro-5-methoxy-1-methyl-1H-1,2,4-triazole (CAS 1330756-15-4)
- [(3Z)-1-[(2,4-Dichlorophenyl)methyl]-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino benzoate (CAS 320419-55-4)
- Carmoterol hydrochloride (CAS 137888-11-0)
- 3-(2,3,4-Trifluorophenyl)pyridin-4-amine (CAS 1258624-27-9)
- N-Allyl-2-(3-hydroxybenzoyl)hydrazinecarbothioamide (CAS 26036-14-6)
- Methyl 6-fluoro-2-methylquinoline-4-carboxylate (CAS 917777-71-0)
- 3,6-Di(pyridin-4-yl)-9H-carbazole (CAS 1446275-54-2)
- Cyclopentyl(3,5-dichlorophenyl)methanone (CAS 898791-90-7)
- (Z)-Butyl 3-phenylacrylate (CAS 52392-65-1)
- 1-[2-Nitro-5-(trifluoromethyl)phenyl]-1H-pyrrole (CAS 1795460-19-3)
- Peptide Impurity 04 (CAS 2913424-91-4)
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