5-(Trifluoromethyl)-1,3-thiazole CAS 1434141-77-1
| CAS No. | 1434141-77-1 |
| Molecular Formula | C4H2F3NS |
| Molecular Weight | 153.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Trifluoromethyl)-1,3-thiazole is closely related to a nitrile group, sulfur-containing functionality, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(Trifluoromethyl)-1,3-thiazole (CAS 1434141-77-1), molecular formula C4H2F3NS and molecular weight 153.13 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 5-(Trifluoromethyl)-1,3-thiazole (C4H2F3NS) contains a nitrile group, sulfur-containing functionality, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 153.13 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2F3NS |
| Molecular Weight | 153.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethyl Standards
- 4-(trifluoromethyl)-1,3-thiazole (CAS 101048-75-3)
- 2-(Trifluoromethyl)thiazole (CAS 1449334-50-2)
- 1-(Trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-amine (CAS 138509-60-1)
- 1-(Trifluoromethyl)cyclopentanamine (CAS 1202965-57-8)
- (R)-2-(Trifluoromethyl)piperidine (CAS 1212734-83-2)
- 1260678-84-9 2-(Trifluoromethyl)cyclopentanamine 2-(trifluoromethyl)cyclopentan-1-amine (CAS 1260678-84-9)
- (3R)-3-(Trifluoromethyl)piperidine (CAS 1282530-77-1)
- 3-(Trifluoromethyl)cyclopentan-1-amine (CAS 1334146-43-8)
Recommended Standards
- 2-Ethynyl-4,5-difluoroaniline (CAS 143101-25-1)
- 4-Ethynyl-2,5-difluoroaniline (CAS 1233521-10-2)
- 2,3-Difluorophenylacetonitrile (CAS 145689-34-5)
- 4-Ethynyl-3,5-difluoroaniline (CAS 1233501-56-8)
- 3-Amino-1-(4-ethylpiperazin-1-yl)propan-1-one (CAS 938339-17-4)
- Ethyl 2-Aminoindole-3-carboxylate (CAS 6433-72-3)
- 2-[(2-cyanophenyl)sulfanyl]acetic acid (CAS 98589-44-7)
- 6-Methoxynaphthalene-1,4-dione (CAS 29263-68-1)
- 1-(1-(Aminomethyl)cyclobutyl)-3-methylcyclopentan-1-ol (CAS 1517048-72-4)
- N-(5-bromo-6-methylpyridin-2-yl)-4-ethylbenzamide (CAS 638141-07-8)
- Metoprolol EP Impurity F (CAS 7695-63-8)
- 7-Bromo-1-methyl-1H-benzo[d]imidazole-5-carboxylic acid hydrochloride (CAS 1420800-33-4)
- Apremilast Impurity 121 (CAS CATO-C4X-1009121)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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