8-Chloro-3,5-dimethylimidazo[1,2-a]pyrazine CAS 143591-89-3
| CAS No. | 143591-89-3 |
| Molecular Formula | C8H8ClN3 |
| Molecular Weight | 181.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-Chloro-3,5-dimethylimidazo[1,2-a]pyrazine (C8H8ClN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
8-Chloro-3,5-dimethylimidazo[1,2-a]pyrazine (CAS 143591-89-3) is a high-purity analytical reference standard with the molecular formula C8H8ClN3 and a molecular weight of 181.62 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8ClN3 |
| Molecular Weight | 181.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-6-methyl-1H-pyrrolo[2,3-b]pyridin-3-amine (CAS 1000340-14-6)
- 4-Chloro-7-methoxy-1H-indole (CAS 1000341-80-9)
- 4-Chloro-5-ethyl-7h-pyrrolo[2,3-d]pyrimidine (CAS 1004992-44-2)
- 4-Chloro-1-ethyl-1H-imidazo[4,5-c]pyridine (CAS 1025509-11-8)
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Recommended Standards
- 8-Chloro-3,6-dimethylimidazo[1,2-a]pyrazine (CAS 143591-87-1)
- 2-(Chloromethyl)-4-methylbenzoxazole (CAS 143708-32-1)
- 6-Chloro-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 14352-35-3)
- 2-(Chloromethyl)-6-methylbenzoxazole (CAS 143708-33-2)
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- 5-(1H-Imidazol-5-yl)oxazole (CAS 1571145-59-9)
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