6-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde CAS 1437433-78-7
| CAS No. | 1437433-78-7 |
| Molecular Formula | C12H21ClN2O2 |
| Molecular Weight | 260.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437433-78-7), molecular formula C12H21ClN2O2 and molecular weight 260.76 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde (C12H21ClN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 6-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H21ClN2O2 |
| Molecular Weight | 260.76 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 7-Chloro-8-methyl-4-(piperidin-1-yl)quinoline (CAS 1072944-74-1)
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- 3-Chloro-1-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)propan-1-one (CAS 1178838-61-3)
- 2-Chloro-N-(2-(N-ethylacetamido)cyclohexyl)acetamide (CAS 1353943-52-8)
- 2-Chloro-N-(4-(N-ethylacetamido)cyclohexyl)acetamide (CAS 1353946-96-9)
- 6-chloro-1-(2-ethoxyethyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437385-39-1)
- 5-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437433-14-1)
- 5-chloro-1-(2-ethoxyethyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437435-07-8)
Recommended Standards
- 7-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437435-49-8)
- 4-(((4-Chlorophenyl)amino)methyl)-N,N-dimethylaniline (CAS 141619-95-6)
- 7-chloro-1-(2-ethoxyethyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437435-68-1)
- 2-(Benzo[b]thiophen-2-yl)ethane-1-sulfonyl chloride (CAS 1415393-42-8)
- 4-Bromo-2-iodo-6-methylaniline (CAS 922170-67-0)
- Methyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine-2-carboxylate (CAS 2377609-07-7)
- O-(3-phenoxypropyl)hydroxylamine hydrochloride (CAS 15269-73-5)
- 3,3-Bis(2-chloro-6-fluorobenzyl)pentane-2,4-dione (CAS 400088-51-9)
- Lusutrombopag Impurity 87 (CAS CATO-C4X-208487)
- 8-Aminoquinoxaline-5-carbonitrile (CAS 573758-47-1)
- 2-Amino-7-bromo-5-methylquinazolin-4(3H)-one (CAS 2454020-13-2)
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- 3-(1-Isopropyl-1,2,3,6-tetrahydropyridin-4-yl)-6-nitro-1H-indole (CAS 1958100-94-1)
- Semaglutide Impurity 144 (CAS 394210-59-4)
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