3-Chloro-1-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)propan-1-one CAS 1178838-61-3
| CAS No. | 1178838-61-3 |
| Molecular Formula | C12H21ClN2O2 |
| Molecular Weight | 260.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chloro-1-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)propan-1-one is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Chloro-1-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)propan-1-one (CAS 1178838-61-3), molecular formula C12H21ClN2O2 and molecular weight 260.76 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-1-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)propan-1-one (C12H21ClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-Chloro-1-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)propan-1-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H21ClN2O2 |
| Molecular Weight | 260.76 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 7-Chloro-8-methyl-4-(piperidin-1-yl)quinoline (CAS 1072944-74-1)
- (S)-3-Chloro-1-phenyl-1-[2-methyl-phenoxyl]propane (CAS 114446-50-3)
- 2-Chloro-N-(2-(N-ethylacetamido)cyclohexyl)acetamide (CAS 1353943-52-8)
- 2-Chloro-N-(4-(N-ethylacetamido)cyclohexyl)acetamide (CAS 1353946-96-9)
- 6-chloro-1-(2-ethoxyethyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437385-39-1)
- 5-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437433-14-1)
- 6-chloro-1-(3-methoxypropyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437433-78-7)
- 5-chloro-1-(2-ethoxyethyl)-1H-1,3-benzodiazole-2-carbaldehyde (CAS 1437435-07-8)
Recommended Standards
- 1-(2-chloroacetyl)-N-methyl-N-(propan-2-yl)piperidine-4-carboxamide (CAS 1311314-48-3)
- Atomoxetine Chloro Impurity (CAS 114446-47-8)
- N1-benzyl-6-chloro-N1-ethylbenzene-1,2-diamine (CAS 1039315-23-5)
- N-((1-(2-Chloroacetyl)piperidin-2-yl)methyl)-N-ethylacetamide (CAS 1353952-27-8)
- 2-((tert-Butoxycarbonyl)amino)-3-fluorobenzoic acid (CAS 141940-30-9)
- N-Boc-1-fluoro-3-methyl-2-butylamine (CAS 942275-75-4)
- α-[3-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-2-methylphenyl]-1H-imidazole-5-methanol (CAS 1240244-29-4)
- N-(4-Bromo-3-methylphenyl)-2-[4-(3-chlorophenyl)piperazin-1-yl]acetamide (CAS 329929-19-3)
- 1-(5-Ethyl-1,2,4-oxadiazol-3-yl)-N-methylmethanamine (CAS 1177321-30-0)
- Ethyl 5-chloro-6-fluoropyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 2359650-50-1)
- 2,2-Dimethyltetrahydro-2H-pyran-4-methanamine Hydrochloride (CAS 1311254-48-4)
- 1-(2-(Piperazin-1-yl)ethyl)pyridin-2(1H)-one (CAS 51323-38-7)
- 5-Methyl-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-4-carboxylic acid (CAS 187998-60-3)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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