4-(5-Chlorothiophen-2-yl)-1-isopropylpiperidin-4-ol CAS 1443310-77-7
| CAS No. | 1443310-77-7 |
| Molecular Formula | C12H18ClNOS |
| Molecular Weight | 259.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(5-Chlorothiophen-2-yl)-1-isopropylpiperidin-4-ol is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-(5-Chlorothiophen-2-yl)-1-isopropylpiperidin-4-ol (CAS 1443310-77-7), molecular formula C12H18ClNOS and molecular weight 259.80 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(5-Chlorothiophen-2-yl)-1-isopropylpiperidin-4-ol (C12H18ClNOS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(5-Chlorothiophen-2-yl)-1-isopropylpiperidin-4-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H18ClNOS |
| Molecular Weight | 259.80 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorothiophen Standards
- 1-[(5-chlorothiophen-2-yl)methyl]piperidine-4-carboxylic acid (CAS 1156269-60-1)
- 2-(5-chlorothiophen-2-yl)-4-methyl-1,3-thiazole-5-carboxylic acid (CAS 1152599-58-0)
- 2-[2-(5-chlorothiophen-2-yl)-1,3-thiazol-4-yl]acetic acid (CAS 1152605-21-4)
- 1-(((5-Chlorothiophen-2-yl)methyl)carbamoyl)cyclopropane-1-carboxylic acid (CAS 1343869-66-8)
- Methyl 5-(5-chlorothiophen-2-yl)-3-methyl-5-oxopentanoate (CAS 1443320-83-9)
- 5-(3-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole (CAS 321537-94-4)
- Ethyl 5-(5-chlorothiophen-2-yl)-5-oxopentanoate (CAS 951889-16-0)
- 2-(4-((5-Chlorothiophen-2-yl)methyl)piperazin-1-yl)ethan-1-ol (CAS 1247902-51-7)
Recommended Standards
- 2,4-dihydro-1h-[1,2,4]triazolo[3,4-c][1,4]benzothiazin-1-one 6289-04-9 AR-1D3615 (CAS 6289-04-9)
- (R)-n-((R)-1-(2-Chlorophenyl)ethyl)-2-methylpropane-2-sulfinamide (CAS 1588938-65-1)
- 3-benzyl-7-chloro-triazolo[4,5-d]pyrimidine (CAS 21410-06-0)
- 6-Chloro-2-(methylthio)-N,N-dipropylpyrimidin-4-amine (CAS 339017-75-3)
- 3,4-Dibenzoyl-2-(4-chlorophenyl)-1-methylpyrrolidine (CAS 1005240-76-5)
- 1-((3-Ethyl-1-methyl-1h-pyrazol-5-yl)methyl)-1h-pyrazol-3-amine (CAS 1481562-94-0)
- 3-[(2-Chloro-4-fluorobenzyl)sulfonyl]-propanoic acid (CAS 702670-31-3)
- 3-[4-(Ethoxycarbonyl)-3,5-dimethyl-1H-pyrrol-2-yl]propanoic acid (CAS 39160-88-8)
- N,N'-Bis[4-(diphenylamino)phenyl]-N,N'-diphenylbenzidine (CAS 209980-53-0)
- 1171385-26-4 3-{[1-(Propan-2-yl)piperidin-4-yl]oxy}propan-1-amine DTXSID40657491 (CAS 1171385-26-4)
- 4,4'-(9,9-Diethyl-9H-fluorene-2,7-diyl)dibenzaldehyde (CAS 2116542-14-2)
- Tert-butyl 3-pentylideneazetidine-1-carboxylate (CAS 1803592-15-5)
- Imidapril Impurity 14 (CAS 157085-05-(free base))
- Neuropeptide Y (13-36) (porcine) (CAS 113662-54-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com