5-(3-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole CAS 321537-94-4
| CAS No. | 321537-94-4 |
| Molecular Formula | C13H9ClN2S |
| Molecular Weight | 260.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(3-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole (CAS 321537-94-4), molecular formula C13H9ClN2S and molecular weight 260.74 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(3-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole (C13H9ClN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 5-(3-Chlorothiophen-2-yl)-1-phenyl-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9ClN2S |
| Molecular Weight | 260.74 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chlorothiophen Standards
- Methyl 5-(5-chlorothiophen-2-yl)-3-methyl-5-oxopentanoate (CAS 1443320-83-9)
- Ethyl 5-(5-chlorothiophen-2-yl)-5-oxopentanoate (CAS 951889-16-0)
- 2-(4-((5-Chlorothiophen-2-yl)methyl)piperazin-1-yl)ethan-1-ol (CAS 1247902-51-7)
- 1-(5-Chlorothiophen-2-yl)-N-((4-methylmorpholin-2-yl)methyl)methanamine (CAS 1355716-66-3)
- 4-(5-Chlorothiophen-2-yl)-1-isopropylpiperidin-4-ol (CAS 1443310-77-7)
- 1-[(5-chlorothiophen-2-yl)methyl]piperidine-4-carboxylic acid (CAS 1156269-60-1)
- (2r)-2-[(5-chlorothiophen-2-yl)formamido]-3-methylbutanoic acid (CAS 1568148-38-8)
- 2-(5-Chlorothiophen-2-yl)-1H-indole-3-carbaldehyde (CAS 590390-91-3)
Recommended Standards
- 5-(3-Chlorophenyl)-2-(prop-2-yn-1-ylsulfanyl)pyrimidine (CAS 344281-98-7)
- 5-(4-Chlorophenyl)-2-(prop-2-yn-1-ylthio)pyrimidine (CAS 344281-59-0)
- 4-Chloro-6-methyl-5-phenylthieno[2,3-d]pyrimidine (CAS 610274-04-9)
- 5-Amino-2-[(4-chlorophenyl)sulfanyl]benzonitrile (CAS 303147-71-9)
- 2-Bromo-4-iodo-6-methylpyridine (CAS 1206248-52-3)
- 5-Methylbenzo[d]thiazol-6-amine (CAS 1782754-28-2)
- 2-Amino-6-chloro-5-(difluoromethyl)nicotinaldehyde (CAS 1805100-39-3)
- (2'-Methoxy-[1,1'-biphenyl]-4-yl)methanol (CAS 885965-14-0)
- Oclacitinib Impurity 14 (CAS CATO-C4X-301814)
- 2-{[1,1'-Biphenyl]-4-yl}indolizine-3-carbaldehyde (CAS 558473-55-5)
- N-Benzyl-3-(3,4-dimethoxyphenyl)propanamide (CAS 40958-49-4)
- 1-(1-(Methylsulfonyl)piperidin-4-yl)ethanone (CAS 1343349-82-5)
- N-(4-acetylphenyl)-2-phenoxyacetamide (CAS 127221-07-2)
- Semaglutide impurity 109 (CAS CATO-C4X-2226109)
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