Methyl 4-(3-chloro-4-fluorophenyl)-4-oxobutanoate CAS 1443322-99-3
| CAS No. | 1443322-99-3 |
| Molecular Formula | C11H10ClFO3 |
| Molecular Weight | 244.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Methyl 4-(3-chloro-4-fluorophenyl)-4-oxobutanoate (C11H10ClFO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 244.65 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Methyl 4-(3-chloro-4-fluorophenyl)-4-oxobutanoate (CAS 1443322-99-3), a certified reference material (molecular formula C11H10ClFO3, MW 244.65 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10ClFO3 |
| Molecular Weight | 244.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
- 2-Acetyl-6-cyanopyridine-4-sulfonyl chloride (CAS 1393570-89-2)
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- 4-chloro-2-(2,2,2-trifluoroethyl)pyrazolo[3,4-d]pyrimidine (CAS 1450917-13-1)
- tert-Butyl {[4-(3-fluorophenyl)piperidin-4-yl]methyl}carbamate (CAS 1158750-59-4)
- 5-Bromo-2,2-dimethyl-2,3-dihydro-1H-inden-1-ol (CAS 371251-54-6)
- 2,3-Dimethyl-2H-pyrazolo[4,3-d]pyrimidin-7-amine (CAS 51222-25-4)
- 4-(Aminomethyl)-2-nitrophenol (CAS 21078-47-7)
- (3R)-3-amino-4,4-dimethyloxolan-2-one (CAS 368436-80-0)
- tert-Butyl 2-(hydroxymethyl)-7,8-dihydro-4H-pyrazolo[1,5-a][1,4]diazepine-5(6H)-carboxylate (CAS 1135282-77-7)
- Fezolinetant Impurity 13 (CAS CATO-C4X-327013)
- tert-Butyl (3S,4S)-3-(dimethylamino)-4-hydroxypyrrolidine-1-carboxylate (CAS 859213-33-5)
- 3-Oxo-2-azabicyclo[2.1.1]Hexane-1-carboxylic acid (CAS 116128-98-4)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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