Ethyl 4-(5-bromo-2-fluorophenoxy)butanoate CAS 1443337-91-4
| CAS No. | 1443337-91-4 |
| Molecular Formula | C12H14BrFO3 |
| Molecular Weight | 305.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ethyl 4-(5-bromo-2-fluorophenoxy)butanoate (CAS 1443337-91-4) is a high-purity analytical reference standard with the molecular formula C12H14BrFO3 and a molecular weight of 305.14 g/mol.
The molecular framework of Ethyl 4-(5-bromo-2-fluorophenoxy)butanoate (C12H14BrFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Ethyl 4-(5-bromo-2-fluorophenoxy)butanoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14BrFO3 |
| Molecular Weight | 305.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Br-containing |
Related Ethyl Standards
- 1-(5-Bromo-2-fluorophenyl)-3-phenylprop-2-en-1-one (CAS 1424701-72-3)
- 2-(2-(2-Bromo-5-fluorophenoxy)ethyl)-1,3-dioxane (CAS 1443306-71-5)
- Ethyl 4-(2-bromo-5-fluorophenoxy)butanoate (CAS 1443329-62-1)
- 2-(2-(4-Bromo-2-fluorophenoxy)ethyl)-1,3-dioxane (CAS 1443329-82-5)
- 2-(2-(3-Bromo-5-fluorophenoxy)ethyl)-1,3-dioxane (CAS 1443343-14-3)
- 2-(2-(4-Bromo-3-fluorophenoxy)ethyl)-1,3-dioxane (CAS 1443349-68-5)
- 2-(2-(5-Bromo-2-fluorophenoxy)ethyl)-1,3-dioxane (CAS 1443354-87-7)
- Ethyl 3-bromo-5-fluoro-2-isopropoxybenzoate (CAS 2112750-69-1)
Recommended Standards
- tert-Butyl (3-(bromomethyl)-4-fluoropyridin-2-yl)carbamate (CAS 1446091-83-3)
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- (2E)-3-(3-Bromophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (CAS 1638607-61-0)
- 4-(N-Boc-aminomethyl)-2-bromo-3-fluoropyridine (CAS 1350885-66-3)
- (2R)-2-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid (CAS 259825-43-9)
- N-(4-Chloro-2-fluorophenyl)-4-methoxybenzamide (CAS 546096-46-2)
- 4-bromo-3-chloro-5-methylbenzoic acid (CAS 1416352-15-2)
- Methyl 2-fluoro-5-formylbenzoate (CAS 165803-94-1)
- Avibactam Impurity 121 (CAS CATO-C4X-1348121)
- 6-chloro-3-methyl-imidazo[4,5-c]pyridine (CAS 7205-45-0)
- (3-Bromo-6-methoxy-pyrazolo[5,1-b]thiazol-7-yl)-carbamic acid tert-butyl ester (CAS 1190854-65-9)
- tert-Butyl (E)-(5-hydroxypent-3-en-1-yl)carbamate (CAS 333438-48-5)
- (2R)-1-(tert-Butoxycarbonyl)-4,4-diethoxypiperidine-2-carboxylic acid (CAS 1212329-25-3)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
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