4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS 1445379-90-7
| CAS No. | 1445379-90-7 |
| Molecular Formula | C32H45ClFN3O4Si2 |
| Molecular Weight | 646.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 1445379-90-7), a certified reference material (molecular formula C32H45ClFN3O4Si2, MW 646.34 g/mol) for analytical method development and quality control.
4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one (C32H45ClFN3O4Si2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H45ClFN3O4Si2 |
| Molecular Weight | 646.34 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related amino Standards
- (S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 1033805-27-4)
- 4-Amino-3-(1-naphthylmethyl)-1H-pyrazolo[3,4-d]pyrimidine-1-(β-D-ribofuranosyl-5-triphosphate) (CAS 476371-81-0)
- Bis [2-[(2-Amino-1,6-dihydro-6-O-benzyl-9H-purin-9yl)methoxy]ethanol] (CAS 1346599-81-2)
- Ethyl 6-amino-2-(((6-(tert-butyl)-3-cyano-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinolin-2-yl)thio)methyl)-5-cyano-4-(thiophen-2-yl)-4H-pyran-3-carboxylate (CAS 497230-56-5)
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Recommended Standards
- 4,4-Difluoro-8-(4'-iodophenyl)-1,7-bis-(1'-napthyl)-4-bora-3alpha,4alpha-diaza-s-indacene (CAS 216255-54-8)
- N4,N4'-bis(3-bromophenyl)-N4,N4'-diphenyl-[1,1'-biphenyl]-4,4'-diamine (CAS 121246-40-0)
- N-Nitroso Amiodarone EP Impurity B (CAS 678982-38-2)
- 5-Bromo-3-(3-((tert-butyldiphenylsilyl)oxy)-2,2-dimethylpropyl)-2-iodo-1H-indole (CAS 2641451-43-4)
- 5-(Benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid (CAS 1219-33-6)
- 9-(Methylsulfonyl)-3-oxa-7,9-diazabicyclo[3.3.1]nonane (CAS 2376607-63-3)
- 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline-3-carbonitrile (CAS 2378308-06-4)
- Boc-D-Homocys(Trt)-OH (CAS 1301706-43-3)
- (E)-6,10-Dimethylundeca-5,9-dien-2-ol (CAS 7733-91-7)
- 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid (CAS 253315-11-6)
- 1-(4-Benzhydrylpiperazin-1-yl)-2-(1h-1,2,4-triazol-1-yl)ethan-1-one (CAS 860788-53-0)
- Tert-butyl 4-(1H-indole-2-carbonyl)piperazine-1-carboxylate (CAS 459168-88-8)
- Hydrocortisone Impurity 45 (CAS 114593-86-1)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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