N-Nitroso Amiodarone EP Impurity B CAS 678982-38-2
| CAS No. | 678982-38-2 |
| Molecular Formula | C23H24I2N2O4 |
| Molecular Weight | 646.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, N-Nitroso Amiodarone EP Impurity B (CAS 678982-38-2, C23H24I2N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
N-Nitroso Amiodarone EP Impurity B (C23H24I2N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures N-Nitroso Amiodarone EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H24I2N2O4 |
| Molecular Weight | 646.26 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-Nitroso Trametinib (CAS CATO-C4X-27823)
- N-Nitroso Sultimicllin EP Impurity D (CAS CATO-C4X-31012)
- N-nitroso Lercanidipine (CAS CATO-C4X-136471)
- N-Nitroso (R)-Candesartan Cilexetil (CAS CATO-C4X-123433)
- N-Nitroso Dabigatran Etexilate (CAS 2892260-29-4)
- N-Nitroso Flupirtine Dimer Impurity 9 (CAS CATO-C4X-10429)
- N-nitroso-elagolix (CAS CATO-C4X-206892)
- Nitroso-prodenafil (CAS 1266755-08-1)
Recommended Standards
- Ceritinib Impurity 61 (CAS CATO-C4X-104861)
- 4,4-Difluoro-8-(4'-iodophenyl)-1,7-bis-(1'-napthyl)-4-bora-3alpha,4alpha-diaza-s-indacene (CAS 216255-54-8)
- Montelukast Methoxymethoxy Impurity (CAS 184764-27-0)
- 4-amino-1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(chloromethyl)-3-fluorotetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 1445379-90-7)
- Clotrimazole Impurity 29 (CAS 103855-36-3)
- Semaglutide impurity 258 (CAS CATO-C4X-2226258)
- LCZ-696 Impurity 31 (CAS CATO-C4X-169631)
- 2-Chloro-N-(4-methoxy-cyclohexyl)-acetamide (CAS 1353998-06-7)
- 5-Cyclopropyl-1-methyl-1H-imidazole-2-carbonitrile (CAS 1403766-95-9)
- 3-((4-Chlorophenyl)sulfonyl)-N-(4,5-dimethylthiazol-2-yl)propanamide (CAS 923422-56-4)
- (E)-N'-[3-Cyano-4-(3,4-dimethoxyphenyl)-4H-benzo[h]chromen-2-yl]-N,N-dimethylmethanimidamide (CAS 845649-71-0)
- 1-(But-3-en-1-yl)-3-methoxybenzene (CAS 1199-90-2)
- 2-Chloro-1-(3,4-difluorophenyl)-2,2-difluoroethan-1-one (CAS 1352215-14-5)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com