2-Chloro-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidine CAS 1445856-64-3
| CAS No. | 1445856-64-3 |
| Molecular Formula | C12H18ClN3OSi |
| Molecular Weight | 283.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Chloro-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidine (CAS 1445856-64-3), a certified reference material (molecular formula C12H18ClN3OSi, MW 283.83 g/mol) for analytical method development and quality control.
The molecular framework of 2-Chloro-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidine (C12H18ClN3OSi) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18ClN3OSi |
| Molecular Weight | 283.83 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-Chloro-3-(dimethoxymethyl)-4-((trimethylsilyl)ethynyl)pyridine (CAS 1171920-13-0)
- 3-Chloro-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine (CAS 1270497-66-9)
- 4-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-c]pyridine (CAS 1609259-33-7)
- 7-Chloro-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[4,5-b]pyridine (CAS 2098583-31-2)
- N'-(6-Chloro-1,3-benzothiazol-2-yl)-N,N-diethylethane-1,2-diamine (CAS 1105195-05-8)
- N1-(5-Chloro-4-methylbenzo[d]thiazol-2-yl)-N3,N3-dimethylpropane-1,3-diamine (CAS 1251614-43-3)
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Recommended Standards
- 4-Chloro-7-cyclohexyl-2-(methylthio)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (CAS 388572-67-6)
- Baricitinib Impurity 15 (CAS 941685-26-3)
- ({4-chloro-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl}methyl)diethylamine (CAS 793727-93-2)
- (9-Oxo-9H-xanthene-2,7-diyl)diboronic Acid (CAS 2133447-57-9)
- Ethyl 1-hydroxy-3,3-dimethylcyclobutane-1-carboxylate (CAS 1936340-44-1)
- 3-(6-Bromo-pyridin-2-yl)-1H-indole (CAS 1146080-40-1)
- 6,6'-((2,2-Bis(((6-carboxynaphthalen-2-yl)oxy)methyl)propane-1,3-diyl)bis(oxy))bis(2-naphthoicacid) (CAS 1352998-95-8)
- 4-[2-[5-Chloro-1,2-dihydro-2-oxo-1-(phenylmethyl)-3H-indol-3-ylidene]hydrazinyl]benzenesulfonamide (CAS 2380245-48-5)
- 1031600-16-4 1-{[2-(4-Methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methyl}piperazine MFCD14281740 (CAS 1031600-16-4)
- 4,6-Bis(2H-benzo[e][1,3]oxazin-3(4H)-yl)-N,N-bis(3-(triethoxysilyl)propyl)-1,3,5-triazin-2-amine (CAS CATO-CIM-105736)
- tert-Butyl 3-(((trifluoromethyl)sulfonyl)oxy)pyrrolidine-1-carboxylate (CAS 1337879-49-8)
- Benzylpenicillin Impurity 73 (CAS CATO-C4X-189973)
- 2-(4-Methyl-1H-pyrazol-1-yl)propanoic acid (CAS 1005582-20-6)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
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