Baricitinib Impurity 15 CAS 941685-26-3
| CAS No. | 941685-26-3 |
| Molecular Formula | C12H18ClN3OSi |
| Molecular Weight | 283.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 283.83 g/mol gives Baricitinib Impurity 15 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Baricitinib Impurity 15 (CAS 941685-26-3, C12H18ClN3OSi) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H18ClN3OSi, Baricitinib Impurity 15 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 283.83 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18ClN3OSi |
| Molecular Weight | 283.83 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Baricitinib Standards
- Baricitinib Impurity 74 (CAS CATO-C4X-226074)
- Baricitinib Impurity 11 (CAS CATO-C4X-226011)
- Baricitinib Impurity 125 (CAS 1416785-38-0)
- Baricitinib Impurity N7 (CAS 1187594-16-6)
- Baricitinib Impurity 124 (CAS CATO-C4X-2260124)
- Baricitinib Impurity 93 (CAS CATO-C4X-226093)
- Baricitinib Impurity 129 (CAS 3043892-25-4)
- Baricitinib Impurity 48 (CAS CATO-C4X-226048)
Recommended Standards
- 7-Chloro-3-((2-(trimethylsilyl)ethoxy)methyl)-3H-imidazo[4,5-b]pyridine (CAS 2098583-31-2)
- N-[2-(4-Chloro-2-methylphenoxy)ethyl]-1-heptanamine (CAS 138323-83-8)
- 4-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-c]pyridine (CAS 1609259-33-7)
- (9-Oxo-9H-xanthene-2,7-diyl)diboronic Acid (CAS 2133447-57-9)
- Oseltamivir Impurity 170 (CAS 122-51-0)
- Olaparib Impurity 23 (CAS 75-26-3)
- Bevantolol Impurity 33 (CAS CATO-C4X-241133)
- Tolvaptan Impurity 61 (CAS 2657689-34-2)
- 3-Difluoromethoxy-4-(trifluoromethoxy)benzonitrile (CAS 1806306-39-7)
- 6-Hydroxy-5-phenyl-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (CAS 39876-28-3)
- (2S,3S)-3-Amino-2-hydroxy-3-(4-(trifluoromethyl)phenyl)propanoic acid (CAS 959574-20-0)
- 785725-61-3 9739AE C11H12ClN3O {2-[5-(2-Chlorophenyl)-1,2,4-oxadiazol-3-yl]-ethyl}methylamine (CAS 785725-61-3)
- 6-(4-Acetylpiperazin-1-yl)-4-methylnicotinonitrile (CAS 1355182-62-5)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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