1-Boc-2-cyanopyrrolidine CAS 144688-70-0
| CAS No. | 144688-70-0 |
| Molecular Formula | C10H16N2O2 |
| Molecular Weight | 196.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Boc-2-cyanopyrrolidine.
1-Boc-2-cyanopyrrolidine (CAS 144688-70-0), molecular formula C10H16N2O2 and molecular weight 196.25 g/mol, is a CATO reference standard with documented purity and traceability.
1-Boc-2-cyanopyrrolidine (C10H16N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Boc-2-cyanopyrrolidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H16N2O2 |
| Molecular Weight | 196.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
Related Boc Standards
- (R)-3-Cyanopyrrolidine-1-sulfonyl chloride (CAS 2301886-37-1)
- (S)-3-Cyanopyrrolidine-1-sulfonyl chloride (CAS 2301083-01-0)
- 1-Cbz-2-cyanopyrrolidine (CAS 119020-06-3)
- Benzyl 3-cyanopyrrolidine-1-carboxylate (CAS 188846-99-3)
- Methyl 2-cyanopyrrolidine-1-carboxylate (CAS 130147-41-0)
- Methyl 1-cyanopyrrolidine-2-carboxylate (CAS 367906-67-0)
- Methyl 1-cyanopyrrolidine-3-carboxylate (CAS 367906-55-6)
- Methyl 4-cyanopyrrolidine-3-carboxylate (CAS 344294-42-4)
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