5,5-Difluoro-2-methyltetrahydro-2H-pyran-2-carboxylic acid CAS 1447942-76-8
| CAS No. | 1447942-76-8 |
| Molecular Formula | C7H10F2O3 |
| Molecular Weight | 180.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5,5-Difluoro-2-methyltetrahydro-2H-pyran-2-carboxylic acid (CAS 1447942-76-8) is a high-purity analytical reference standard with the molecular formula C7H10F2O3 and a molecular weight of 180.15 g/mol.
The molecular framework of 5,5-Difluoro-2-methyltetrahydro-2H-pyran-2-carboxylic acid (C7H10F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 5,5-Difluoro-2-methyltetrahydro-2H-pyran-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H10F2O3 |
| Molecular Weight | 180.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Difluoro Standards
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- Ethyl 5,5-difluoro-4-oxopentanoate (CAS 1161004-57-4)
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- 2,2-difluoro-2-(pyrazin-2-yl)acetic acid (CAS 1342462-39-8)
- Ethyl 3,3-difluoro-2-hydroxypent-4-enoate (CAS 1365970-40-6)
- (R)-5,5-difluoro-2-methyltetrahydro-2H-pyran-2-carboxylic acid (CAS 1447941-12-9)
- (S)-5,5-difluoro-2-methyltetrahydro-2H-pyran-2-carboxylic acid (CAS 1447942-80-4)
Recommended Standards
- 3-(difluoromethyl)pyrazine-2-carboxylic acid (CAS 1443287-46-4)
- 3-(3,5-Difluorophenyl)-1H-pyrazole (CAS 154258-58-9)
- 4,7-Difluoronaphthalen-1-ol (CAS 1402004-56-1)
- 3-(2,6-Difluorophenyl)pyrazole (CAS 154258-88-5)
- 4-Bromo-2-chloro-1-iodobenzene (CAS 31928-47-9)
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- 2-(2,4-Difluorophenyl)allyl acetate (CAS 149809-34-7)
- spiro[2.3]hexane-5-carbaldehyde (CAS 1780698-50-1)
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