1-(4-((3-Bromopyridin-2-yl)oxy)piperidin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one CAS 1448139-57-8
| CAS No. | 1448139-57-8 |
| Molecular Formula | C17H17BrN2O2S |
| Molecular Weight | 393.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(4-((3-Bromopyridin-2-yl)oxy)piperidin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one.
1-(4-((3-Bromopyridin-2-yl)oxy)piperidin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one (CAS 1448139-57-8) is a high-purity analytical reference standard with the molecular formula C17H17BrN2O2S and a molecular weight of 393.30 g/mol.
The molecular framework of 1-(4-((3-Bromopyridin-2-yl)oxy)piperidin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one (C17H17BrN2O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(4-((3-Bromopyridin-2-yl)oxy)piperidin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H17BrN2O2S |
| Molecular Weight | 393.30 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bromopyridin Standards
- Methyl 1-(5-bromopyridin-2-yl)-5-(2-chlorophenyl)-1H-pyrazole-4-carboxylate (CAS 1150164-70-7)
- 4-(2-(6-Bromopyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline (CAS 476475-03-3)
- 3-(4-(5-Bromopyridin-2-yl)tetrahydro-2H-pyran-4-yl)-5-(pyridin-3-yl)-1,2,4-oxadiazole (CAS 1369514-00-0)
- 3-(4-(5-Bromopyridin-2-yl)tetrahydro-2H-pyran-4-yl)-5-(pyridin-4-yl)-1,2,4-oxadiazole (CAS 1369514-01-1)
- (S)-4-(3-Bromopyridin-4-yl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylic acid 1786468-03-8 (CAS 1786468-03-8)
- (S)-4-(2-Bromopyridin-3-yl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylic acid 1786517-17-6 (CAS 1786517-17-6)
- (S)-4-(4-Bromopyridin-2-yl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylic acid 1786525-42-5 (CAS 1786525-42-5)
- (S)-4-(6-Bromopyridin-3-yl)-1-(tert-butoxycarbonyl)-piperazine-2-carboxylic acid 1786603-14-2 (CAS 1786603-14-2)
Recommended Standards
- 4-(4'-Bromo-[1,1'-biphenyl]-4-yl)-2-(pyridin-3-yl)thiazole (CAS 1421263-56-0)
- 5-Bromo-3-isopropyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine (CAS 1620574-97-1)
- N-(3-Bromophenyl)-2-((4-(pyrrolidin-1-yl)pyrimidin-2-yl)thio)acetamide (CAS 1251546-02-7)
- 1,1-Bis(4-chlorophenyl)-2-((4-fluorophenyl)thio)ethanol (CAS 303152-19-4)
- Ozagrel Impurity 12 (CAS 74003-18-2)
- 4'-Butyl-[1,1'-biphenyl]-4-carboxylic acid (CAS 59662-46-3)
- 3-Ethoxy-4-iodobenzoic acid (CAS 933672-16-3)
- (Dimethylamino)methyl methyl ether (CAS 62393-45-7)
- 1-methyl-4-(trifluoromethyl)-Naphthalene (CAS 52331-42-7)
- 6-(Thiophen-2-yl)pyridazine-3-thiol (CAS 134252-09-8)
- 4-Methyl-2-(phenylamino)pyrimidine-5-carboxylic acid (CAS 23155-58-0)
- Tulobuterol Impurity 22 (CAS 5639-00-9)
- 6-Hydroxy-1,2,3,4-tetrahydroquinoline (CAS 3373-00-0)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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