N6-Benzoyl-2�-deoxy-5�-O-trityladenosine-3�-O-diisopropylaminocyanoethylphosphoramidite CAS 144846-12-8
| CAS No. | 144846-12-8 |
| Molecular Formula | C45H48N7O5P |
| Molecular Weight | 797.88 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N6-Benzoyl-2�-deoxy-5�-O-trityladenosine-3�-O-diisopropylaminocyanoethylphosphoramidite.
N6-Benzoyl-2�-deoxy-5�-O-trityladenosine-3�-O-diisopropylaminocyanoethylphosphoramidite (CAS 144846-12-8), molecular formula C45H48N7O5P and molecular weight 797.88 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, N6-Benzoyl-2�-deoxy-5�-O-trityladenosine-3�-O-diisopropylaminocyanoethylphosphoramidite (C45H48N7O5P) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 25.5, corresponding to approximately 25 ring(s) or double-bond equivalent(s). With a molecular weight of 797.88 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N6-Benzoyl-2�-deoxy-5�-O-trityladenosine-3�-O-diisopropylaminocyanoethylphosphoramidite meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C45H48N7O5P |
| Molecular Weight | 797.88 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 25.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 7 |
Related N Standards
- N6-Benzoyl-2�-3'-dideoxy-3�-tritylaminotrityladenosine-5�-O-diisopropylaminocyanoethylphosphoramidit (CAS 195375-64-5)
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- N4-Benzoyl-2-O-tert-butyldimethylsilyl-5-O-DMT-cytidine (CAS 81256-87-3)
- (N4-Benzoyl)-5-O-[(N,N-diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3-O-(4,4-dimethoxytrityl)-2-deoxycytidine (CAS 140712-83-0)
Recommended Standards
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- (S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS 182625-68-9)
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