(5-Bromo-2-chloro-4-(trifluoromethyl)phenyl)boronic acid CAS 1452574-71-8

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (5-Bromo-2-chloro-4-(trifluoromethyl)phenyl)boronic acid.

(5-Bromo-2-chloro-4-(trifluoromethyl)phenyl)boronic acid (CAS 1452574-71-8) is a high-purity analytical reference standard with the molecular formula C7H4BBrClF3O2 and a molecular weight of 303.27 g/mol.

Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, (5-Bromo-2-chloro-4-(trifluoromethyl)phenyl)boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 303.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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