Silodosin Impurity N44 CAS 1453221-45-8
| CAS No. | 1453221-45-8 |
| Molecular Formula | C35H41F6N3O6 |
| Molecular Weight | 713.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Silodosin Impurity N44 (CAS 1453221-45-8) is a certified pharmaceutical impurity reference standard with the molecular formula C35H41F6N3O6 and a molecular weight of 713.71 g/mol.
The molecular framework of Silodosin Impurity N44 (C35H41F6N3O6) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Silodosin Impurity N44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C35H41F6N3O6 |
| Molecular Weight | 713.71 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Silodosin Standards
- Silodosin O-ß-D-Glucuronide-D4 (CAS 879396-70-0 (unlabeled))
- Silodosin Glucuronide-D4 (CAS 2851016-14-1)
- Silodosin Glucuronide (CAS 879396-70-0)
- Silodosin impurity 22 (CAS CATO-C4X-175422)
- Silodosin Impurity N99 (CAS 885340-11-4)
- Silodosin impurity 19 (CAS CATO-C4X-175419)
- Silodosin N-Oxide (CAS 2361272-05-9)
- Silodosin N-Nitroso Impurity 21 (CAS CATO-C4X-175421)
Recommended Standards
- 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(1S,2S)-2-[(11bR)-3,5-dihydro-4H-dinaphth[2,1-c:1',2'-e]azepin-4-yl]cyclohexyl]amino]-3-cyclobutene-1,2-dione (CAS 1323997-09-6)
- RETF-4NA (CAS 1160928-63-1)
- Perchlorocoronene (CAS 94227-23-3)
- L-Tryptophan, 1-[(1,1-dimethylethoxy)carbonyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2-carboxy-2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl ester (CAS 944283-24-3)
- Bimatoprost Impurity 24 (CAS CATO-C4X-196424)
- Phytomenadione/Vitamin K1 Impurity 133 (CAS 854039-21-7)
- Faropenem Impurity 90 (CAS CATO-C4X-128990)
- 6,7-Dihydrothieno[3,2-d]pyrimidine-2,4-diol (CAS 913581-92-7)
- Polymyxin Impurity 26 (CAS CATO-C4X-225526)
- 3-(2,3,6-Trifluorophenyl)acrylic acid (CAS 230295-12-2)
- 5-Azaspiro[2.4]heptane-1-carboxylic acid (CAS 746577-57-1)
- 4-Butoxy-3-iodoaniline (CAS 1484654-79-6)
- 926205-24-5 N-(3-Amino-2-methylphenyl)nicotinamide (CAS 926205-24-5)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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