Silodosin impurity 22 CAS CATO-C4X-175422
| CAS No. | CATO-C4X-175422 |
| Molecular Formula | C32H33F3N4O5 |
| Molecular Weight | 610.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Silodosin impurity 22.
CATO supplies Silodosin impurity 22 (CAS CATO-C4X-175422), a pharmacopoeial impurity reference standard (molecular formula C32H33F3N4O5, MW 610.62 g/mol) used for the identification and quantification of trace impurities in APIs.
Silodosin impurity 22 (C32H33F3N4O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H33F3N4O5 |
| Molecular Weight | 610.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Silodosin Standards
- Silodosin Impurity N99 (CAS 885340-11-4)
- Silodosin Glucuronide (CAS 879396-70-0)
- Silodosin O-ß-D-Glucuronide-D4 (CAS 879396-70-0 (unlabeled))
- Silodosin Glucuronide-D4 (CAS 2851016-14-1)
- Silodosin impurity 19 (CAS CATO-C4X-175419)
- Silodosin N-Oxide (CAS 2361272-05-9)
- Silodosin N-Nitroso Impurity 21 (CAS CATO-C4X-175421)
- Silodosin Carboxylic Acid Impurity (CAS 1357252-79-9)
Recommended Standards
- Axitinib Impurity 42 (CAS 808142-24-7)
- Suc-Ala-Gly-Pro-Phe-pNA (CAS 128802-77-7)
- KPT 9274 (ATG-019) (CAS 1643913-93-2)
- (5S,8S,11S,14S)-Methyl 14-(2-Fluoroacetyl)-11-isopropyl-8-(3-methoxy-3-oxopropyl)-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate (CAS 1135688-47-9)
- Roxatidine Impurity 26 (CAS CATO-C4X-121326)
- Ketorolac Impurity 46 (CAS 144710-34-9)
- Dabrafenib Impurity 9 (CAS CATO-C4X-30339)
- Docetaxel Impurity 57 (CAS CATO-C4X-161957)
- 2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione (CAS 835616-61-0)
- 4-Ethylbenzyl thiocyanate (CAS 112028-24-7)
- 5-(propan-2-yl)pyrrolidin-2-one (CAS 81659-64-5)
- 2,5-Dibromo-3-nitropyrazine (CAS 1245645-88-8)
- methyl 2-amino-4-fluoro-2-methylbutanoate (CAS 1446499-77-9)
- ([D2]Gly4)-Cholecystokinin Octapeptide (sulfated) ammonium salt (CAS 1926163-74-7)
Why CATO?
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