Simvastatin EP Impurity B CAS 145576-25-6
| CAS No. | 145576-25-6 |
| Molecular Formula | C27H40O6 |
| Molecular Weight | 460.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Simvastatin EP Impurity B is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Simvastatin EP Impurity B (CAS 145576-25-6, C27H40O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Simvastatin EP Impurity B (C27H40O6) contains a steroid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Simvastatin EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H40O6 |
| Molecular Weight | 460.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
Related Simvastatin Standards
- Simvastatin Impurity M (CAS 1796930-96-5)
- Simvastatin EP Impurity M (CAS 864357-87-9)
- Simvastatin acid-d (CAS 1309272-51-2)
- Simvastatin Methyl Ester (CAS 145576-26-7)
- Simvastatin impurity 01 (CAS 1092716-42-1)
- Simvastatin EP Impurity J (CAS 864357-88-0)
- Simvastatin EP Impurity N (Mixture of Diastereomers) (CAS 774611-54-0)
- Simvastatin Impurity 8 (CAS 130468-11-0)
Recommended Standards
- Cholic Acid Impurity 68 (CAS 7753-73-3)
- Travoprost Impurity 43 (CAS CATO-C4X-192543)
- (-)-Sophoranone (CAS 23057-55-8)
- Latanoprost EP Impurity C (CAS CATO-C4X-194117)
- Alogliptin impurity 80 (CAS 2819242-71-0（free base）)
- Esomeprazole Impurity 68 (CAS 2512216-37-2)
- Roflumilast Impurity 27 (CAS 74976-40-2)
- 3-(3-(Benzyloxy)phenyl)propanoic acid (CAS 57668-34-5)
- 4-Chloropropiophenone (CAS 6285-05-8)
- 5-(Piperidine-1-sulfonyl)-2-(2,2,2-trifluoro-ethoxy)-phenylamine (CAS 556016-29-6)
- Dichloro(1,2-bis((2S,5S)-2,5 dimethylphospholanobenzene)(2-(diphenylphosphino)ethylamine)-ruthenium(II) (CAS 2080413-09-6)
- 3-(Heptyloxy)benzaldehyde (CAS 80407-63-2)
- 2-(3,4-Dihydro-2h-1-benzopyran-6-yl)propanoic acid (CAS 63476-57-3)
- [β-Asp]9-Semaglutide (CAS CATO-CPTD788605)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com