(2R,3R,4S,5R)-2-(6-Amino-2-bromo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol CAS 146-76-9
| CAS No. | 146-76-9 |
| Molecular Formula | C10H12BrN5O4 |
| Molecular Weight | 346.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2R,3R,4S,5R)-2-(6-Amino-2-bromo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (CAS 146-76-9), molecular formula C10H12BrN5O4 and molecular weight 346.14 g/mol, is a CATO reference standard with documented purity and traceability.
(2R,3R,4S,5R)-2-(6-Amino-2-bromo-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (C10H12BrN5O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12BrN5O4 |
| Molecular Weight | 346.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Recommended Standards
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- 2-(Tributylstannyl)-2-propen-1-amine (CAS 155258-22-3)
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- 2-(Methylthio)-1H-naphtho[1,2-d]imidazole (CAS 40507-62-8)
- methyl (1S,3S)-3-aminocyclohexane-1-carboxylate hydrochloride (CAS 1461718-75-1)
- (1R)-(+)-trans-Pinane (CAS 4863-59-6)
- 5-Bromo-1-methyl-1H-pyrrole-2-carbonitrile (CAS 1648837-65-3)
- 5-Chloro-n-methylthiophene-2-sulfonamide (CAS 67060-79-1)
- Methyl 5-amino-2-methylisonicotinate (CAS 860369-48-8)
- Insulin Degludec Impurity 12 (CAS CATO-C4X-215712)
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