Bosutinib Impurity 5 CAS 1460227-29-5
| CAS No. | 1460227-29-5 |
| Molecular Formula | C18H13Cl2N3O3 |
| Molecular Weight | 390.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C18H13Cl2N3O3, Bosutinib Impurity 5 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 390.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Bosutinib Impurity 5 (CAS 1460227-29-5, C18H13Cl2N3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bosutinib Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13Cl2N3O3 |
| Molecular Weight | 390.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Bosutinib Standards
- Bosutinib Impurity 8 (CAS 2095306-22-0)
- Bosutinib Impurity 19 (CAS 380843-12-9)
- Bosutinib Impurity 4 (CAS 492444-39-0)
- Bosutinib Impurity 11 (CAS CATO-C4X-184711)
- Bosutinib Impurity 3 (CAS CATO-C4X-18473)
- Bosutinib Impurity 14 (CAS CATO-C4X-184714)
- Bosutinib Impurity 24 (CAS 380844-49-5)
- Bosutinib 4-Chloro 7-Chloropropoxy Impurity (CAS 214470-68-5)
Recommended Standards
- Pemetrexed Impurity 69 (CAS CATO-C4X-172669)
- Lifitegrast Impurity 5 (CAS 2129597-34-6)
- Tert-butyl (R)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate (CAS 1374971-66-0)
- (2E)-3-(6-Bromo-2H-1,3-benzodioxol-5-yl)-N-[(2-methoxyphenyl)methyl]prop-2-enamide (CAS 1164476-09-8)
- Loxoprofen Impurity 41 (CAS 50882-16-1)
- Procaine Impurity 4 HCl (CAS 10367-96-1(free base))
- Ursodeoxycholic Acid impurity 83 (CAS 21066-20-6)
- 2-Azido-1-(2-methyl-1H-indol-3-yl)ethanone (CAS 1858256-28-6)
- 2,8-Dimethoxyquinazoline-6-carboxylic acid (CAS 2721375-00-2)
- 2,6-Difluoro-4-(trifluoromethoxy)phenol (CAS 2383766-24-1)
- 4-Amino-3H-imidazo[4,5-c]pyridine (CAS 6811-77-4)
- 4-(6-Bromo-1,3-benzothiazol-2-yl)-1,2,5-oxadiazol-3-amine (CAS 1536334-84-5)
- 4-Methylquinoline-2-carboxylic acid (CAS 40609-76-5)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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