Bosutinib Impurity 4 CAS 492444-39-0
| CAS No. | 492444-39-0 |
| Molecular Formula | C19H23ClN4O2 |
| Molecular Weight | 374.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bosutinib Impurity 4.
Bosutinib Impurity 4 (CAS 492444-39-0) is a certified pharmaceutical impurity reference standard with the molecular formula C19H23ClN4O2 and a molecular weight of 374.86 g/mol.
Bosutinib Impurity 4 (C19H23ClN4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H23ClN4O2 |
| Molecular Weight | 374.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Bosutinib Standards
- Bosutinib Impurity 8 (CAS 2095306-22-0)
- Bosutinib Impurity 5 (CAS 1460227-29-5)
- Bosutinib Impurity 11 (CAS CATO-C4X-184711)
- Bosutinib Impurity 19 (CAS 380843-12-9)
- Bosutinib 4-Chloro 7-Chloropropoxy Impurity (CAS 214470-68-5)
- Bosutinib Impurity 3 (CAS CATO-C4X-18473)
- Bosutinib 4-Hydroxy 7-Chloropropoxy Impurity (CAS 214470-66-3)
- Bosutinib Impurity 10 (CAS 219786-51-3)
Recommended Standards
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- tert-Butyl 2-cyclohexylideneacetate (CAS 53138-75-3)
- 2-(Difluoromethyl)-3-methoxypyridine-4-methanol (CAS 1806062-46-3)
- Calcium tin oxide, 99% (metals basis excluding Mg), Mg (CAS 12013-46-6)
- 3-Cyclopropoxy-6-(methylthio)picolinamide (CAS 1243450-55-6)
- 3,5-Dichloro-4-cyanobenzoic acid (CAS 90008-06-3)
- Desmethyl Fluvoxamine-β-D-Glucuronide (CAS 89103-66-2)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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