Lafutidine impurity 17（Z-Isomer） CAS 146270-03-3
| CAS No. | 146270-03-3 |
| Molecular Formula | C15H21ClN2O |
| Molecular Weight | 280.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lafutidine impurity 17（Z-Isomer） (CAS 146270-03-3, C15H21ClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lafutidine impurity 17（Z-Isomer） (C15H21ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H21ClN2O |
| Molecular Weight | 280.79 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lafutidine Standards
- Lafutidine Impurity 27 (CAS CATO-C4X-147627)
- Lafutidine impurity 21 (CAS CATO-C4X-147621)
- Lafutidine impurity 16 (CAS 129622-98-6)
- Lafutidine Impurity 7 (CAS 1710725-58-8)
- Lafutidine Impurity 10 (CAS 103922-89-0)
- Lafutidine Impurity 3 (CAS 103922-84-5)
- Lafutidine Impurity 11 (CAS 154923-16-7)
- Lafutidine Impurity 8 (CAS 169899-15-4)
Recommended Standards
- N-(4-Chlorophenyl)-2-((cyclohexylmethyl)amino)acetamide (CAS 338428-43-6)
- n-(3-Chloro-4-methylphenyl)-2-(cyclohexylamino)acetamide (CAS 332908-84-6)
- Mepivacaine EP Impurity E (CAS 2717331-30-9)
- n-(1-Benzylpiperidin-4-yl)-2-chloropropanamide (CAS 334974-43-5)
- Triamcinolone Acetonide Impurity 49 (CAS 7704-77-0)
- Roxadustat Impurity 131 (CAS CATO-C4X-2213131)
- Norepinephrine Impurity 107 (CAS 112346-92-6)
- Methyl Tetradecanoate-d27 (CAS 434349-93-6)
- 4-Methyl-2-((3-nitropyridin-2-yl)thio)pyrimidine (CAS 73768-44-2)
- (S)-Ethyl 3-hydroxy-3-phenylpropanoate (CAS 33401-74-0)
- Midazolam EP Impurity D (CAS 59468-83-6)
- N-(benzoyloxy)-N-phenylbenzamide (CAS 16817-95-1)
- 2-(2-(1,5-Dimethyl-1h-pyrazol-4-yl)-1h-benzo[d]imidazol-1-yl)acetic acid (CAS 1152964-57-2)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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