Roxadustat Impurity 131 CAS CATO-C4X-2213131
| CAS No. | CATO-C4X-2213131 |
| Molecular Formula | C12H10BrNO3 |
| Molecular Weight | 296.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 296.12 g/mol gives Roxadustat Impurity 131 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Roxadustat Impurity 131 (CAS CATO-C4X-2213131) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10BrNO3 and a molecular weight of 296.12 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Roxadustat Impurity 131 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 296.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10BrNO3 |
| Molecular Weight | 296.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 64 (CAS 1509958-11-5)
- Roxadustat Impurity 9 (CAS 1421312-35-7)
- Roxadustat Impurity 99 (CAS CATO-C4X-221399)
- Roxadustat Impurity N15 (CAS 1455091-10-7)
- Roxadustat Impurity N14 (CAS 2243809-28-9)
- Roxadustat Impurity 12 (CAS CATO-C4X-221312)
- Roxadustat Impurity 160 (CAS CATO-C4X-2213160)
- Roxadustat Impurity 163 (CAS 62202-62-4)
Recommended Standards
- n-(4-Bromo-3-methylphenyl)-2-(1h-tetrazol-1-yl)acetamide (CAS 791127-56-5)
- 3-(((2-Bromo-4-fluorophenyl)amino)methyl)phenol (CAS 1039874-24-2)
- n-(4-Bromo-2-methylphenyl)-2-(1h-tetrazol-1-yl)acetamide (CAS 923800-54-8)
- 2,4-Dichloro-7-(2-fluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1075205-27-4)
- Hydrocortisone Impurity 73 (CAS CATO-C4X-140173)
- Brivaracetam Impurity 125 (CAS CATO-C4X-2007125)
- Pomalidomide Impurity 50 (CAS CATO-C4X-135450)
- Ethyl (s)-3-amino-3-(thiophen-3-yl)propanoate (CAS 1307224-69-6)
- Ethyl 6-methoxy-2-methylimidazo[1,2-a]pyrazine-3-carboxylate (CAS 2121305-12-0)
- 1-(5-Hexylisoxazol-3-yl)ethanone (CAS 491841-08-8)
- Roxadustat Impurity 33 (CAS 1455091-04-9)
- Ammonium dichloride, iridium(III) chloride (CAS 15742-38-8)
- 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine (CAS 1612287-99-6)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788694)
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