4-Chloro-6-(4-fluorophenyl)-5-methylpyrimidine CAS 1465075-53-9
| CAS No. | 1465075-53-9 |
| Molecular Formula | C11H8ClFN2 |
| Molecular Weight | 222.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-6-(4-fluorophenyl)-5-methylpyrimidine.
4-Chloro-6-(4-fluorophenyl)-5-methylpyrimidine (CAS 1465075-53-9), molecular formula C11H8ClFN2 and molecular weight 222.65 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-Chloro-6-(4-fluorophenyl)-5-methylpyrimidine (C11H8ClFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 222.65 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Chloro-6-(4-fluorophenyl)-5-methylpyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8ClFN2 |
| Molecular Weight | 222.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-5-fluoro-6-methyl-2-phenylpyrimidine (CAS 1000931-50-9)
- 4-Chloro-2-[(4-fluorophenyl)methyl]pyrimidine (CAS 1156238-27-5)
- 4-chloro-6-(2-fluorophenyl)-2-methylpyrimidine (CAS 1159816-02-0)
- 3-Chloro-6-(2-fluorophenyl)-4-methylpyridazine (CAS 118270-17-0)
- 3-Chloro-4-methoxybenzenesulfonic acid (CAS 118795-71-4)
- 4-Chloro-2-(2-fluorophenyl)-6-methylpyrimidine (CAS 1188233-71-7)
- 2-Chloro-6-methoxypyridine-3-sulfonamide (CAS 1208081-15-5)
- 4-chloro-6-(3-fluorophenyl)-2-methylpyrimidine (CAS 1256638-62-6)
Recommended Standards
- 4-Chloro-2-(4-fluorophenyl)-6-methylpyrimidine (CAS 142220-65-3)
- 2-chloro-4-(2-fluorophenyl)-5-methylpyrimidine (CAS 1537572-82-9)
- 4-Chloro-3-(4-fluorophenyl)pyridin-2-amine (CAS 1381941-98-5)
- (5-Cyclopropyl-1,2,4-oxadiazol-3-yl)methanesulfonyl chloride (CAS 1597298-23-1)
- 9H-Fluorene-3,9-diol (CAS 1381944-22-4)
- 1-(4-Chlorobenzenesulfonyl)-3-[1-({2-fluoro-[1,1'-biphenyl]-4-yl}oxy)ethyl]-1H-pyrazole (CAS 477711-04-9)
- N-butyl-6-chloro-N-ethylpyrazin-2-amine (CAS 1250890-84-6)
- m-PEG10-alcohol (CAS 27425-92-9)
- N-benzyl-3-((2,4-dimethylphenyl)sulfonyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 904588-79-0)
- 2,6-Dichloro-4-methylbenzyl bromide (CAS 1807183-11-4)
- 1,1,2,4,4,5,5-heptafluoro-3,3-bis(trifluoromethyl)-1-hexene 1,1,2,4,4,5,5-heptakis(fluoranyl)-3,3-bis(trifluoromethyl)hex-1-ene 79272-26-7 A839633 (CAS 79272-26-7)
- Ethyl 2-Acetamido-2-ethoxycarbonyl-3-(2-ethyl-5-methyl-3-oxoisoxazolin-4-yl) propionate (CAS 127020-33-1)
- 4-Bromo-1-(2,2-difluoropropyl)-1H-imidazole (CAS 2167183-58-4)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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